Neostriatum

The neostriatum or striatum is a key component of the basal ganglia which is involved in a wide range of neurological functions including movement control, cognitive processing, and reward-based learning. The striatum is made up of two distinct subregions, the caudate nucleus and the putamen, which are interconnected by a series of neural pathways. Neurological research has revealed insights into the role of the neostriatum in a variety of neurological disorders, including Parkinson's disease, Huntington's disease, and Tourette's syndrome. Studies have shown that these disorders are associated with alterations in the function of specific neurotransmitters, including dopamine and acetylcholine, which activate distinct neural pathways within the neostriatum. Therapy for these disorders often involves pharmacological approaches, such as dopamine agonists or antagonists, or surgical interventions, such as deep brain stimulation. However, recent research has also focused on the development of non-invasive techniques such as transcranial magnetic stimulation and transcranial direct current stimulation to modulate the activity of the neostriatum. In summary, the neostriatum is a crucial component of the basal ganglia that plays a critical role in a wide range of neurological functions. Understanding the underlying neurobiology of the neostriatum and its involvement in neurological disorders is essential for the development of innovative therapies and interventions that can improve the lives and wellbeing of individuals affected by these disorders.


From: Neurobiology

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Editor-in-chief: Zheng Jiang, Department of Neuroscience, The Johns Hopkins University School of Medicine.
Publication Type: Open Access Journal
Description: The brain, spinal cord, and nerves make up the nervous system. Together they control all the workings of the body. When something goes wrong with a part of your nervous system, you can have trouble moving, speaking, swallowing, breathing, or learning. You can also have problems with your memory, senses, or mood.