Deformation-based Morphometry

Deformation-based morphometry (DBM) is a cutting-edge imaging technique used in neurological research and therapy to study changes in brain structure and function. It is a powerful tool that allows scientists to identify structural differences in the brain, both in healthy individuals and those suffering from neurological disorders or injuries. DBM involves the use of magnetic resonance imaging (MRI) to generate 3D images of the brain. These images are then analyzed to identify differences in the shape and size of particular brain structures, such as the hippocampus, amygdala, basal ganglia, and cerebral cortex. The technique works by comparing differences in the coordinates of specific points in the brain using sophisticated algorithms. By measuring the degree of deformation at each point, DBM can reveal subtle structural changes that may not be visible with other imaging techniques. One major application of DBM is in the study of neurodegenerative diseases such as Alzheimer's and Parkinson's. Researchers use DBM to identify changes in brain structure that occur as the disease progresses, allowing them to better understand the underlying mechanisms of these disorders. DBM is also used in neurological therapy, particularly in the treatment of traumatic brain injury (TBI). By analyzing changes in brain structure following injury, therapists can tailor treatment plans to the specific needs of each patient, helping them to recover more quickly and completely. Overall, deformation-based morphometry is a powerful tool for studying the brain and its role in neurological function and dysfunction. With continued advances in imaging technology and data analysis techniques, DBM holds great promise for unlocking new insights into the workings of the human brain.

From: Neurobiology

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Editor-in-chief: Zheng Jiang, Department of Neuroscience, The Johns Hopkins University School of Medicine.
Publication Type: Open Access Journal
Description: The brain, spinal cord, and nerves make up the nervous system. Together they control all the workings of the body. When something goes wrong with a part of your nervous system, you can have trouble moving, speaking, swallowing, breathing, or learning. You can also have problems with your memory, senses, or mood.