Nuclear magnetic resonance (NMR) is a spectroscopic technique that exploits the magnetic properties of atomic nuclei possessing spin, such as hydrogen-1, carbon-13 and nitrogen-15, to probe molecular structure and dynamics. When placed in a strong magnetic field and irradiated with radiofrequency energy, these nucle…
Nuclear magnetic resonance (NMR) is a spectroscopic technique that exploits the magnetic properties of atomic nuclei possessing spin, such as hydrogen-1, carbon-13 and nitrogen-15, to probe molecular structure and dynamics. When placed in a strong magnetic field and irradiated with radiofrequency energy, these nuclei resonate at frequencies exquisitely sensitive to their local electronic and chemical environment. The resulting spectra reveal which atoms are present, how they are connected, and how they move, making NMR one of the most informative non-destructive methods in chemistry and biology. In structural biology, multidimensional NMR is used to determine the three-dimensional structures of proteins and nucleic acids in solution, to map binding interfaces, and to characterise conformational change and flexibility that crystallographic methods may not capture. Chemical-shift, coupling and relaxation parameters together encode information about distance, connectivity and motion, allowing atom-level models of macromolecules and their complexes. Beyond structure determination, NMR supports metabolite profiling, ligand screening and the analysis of small molecules and natural products. As a complement to X-ray crystallography and cryo-electron microscopy, it is distinctive in studying molecules in near-physiological conditions and in resolving dynamic behaviour, providing insight into how biomolecular structure relates to function across a wide range of systems.
10 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 10 articles above have been cited 37 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Nuclear Magnetic Resonance, linking to each citing work.