Senile Plaques

Senile plaques are a common feature in the brains of individuals affected by Alzheimer's disease (AD). These plaques consist of a build-up of beta-amyloid protein peptides, which can accumulate and form dense clusters around the brain cells. Over time, these plaques can cause inflammation and disrupt the normal functioning of brain cells, ultimately leading to cognitive decline and memory loss associated with AD. Research into senile plaques has focused on the development of effective therapies for treating AD. One approach involves the use of antibodies that can bind specifically to beta-amyloid, and stimulate the immune system to clear the plaques from the brain. Another strategy involves reducing the production of beta-amyloid peptides through the inhibition of certain enzymes that are involved in their production. Therapies targeting senile plaques hold great promise for treating AD and improving the quality of life for millions of affected individuals. However, clinical trials thus far have had mixed results, highlighting the need for continued research and the identification of alternative treatment approaches. Researchers are now exploring the role of other factors, such as inflammation and genetic risk factors, in the development of senile plaques and AD. In conclusion, senile plaques are an important focus of neurological research and therapy for their role in the development of Alzheimer's disease. Continued efforts to understand the mechanisms underlying the formation of these plaques and their effects on brain function are critical for the development of effective treatments and ultimately a cure for this debilitating condition.

From: Neurobiology

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Editor-in-chief: Zheng Jiang, Department of Neuroscience, The Johns Hopkins University School of Medicine.
Publication Type: Open Access Journal
Description: The brain, spinal cord, and nerves make up the nervous system. Together they control all the workings of the body. When something goes wrong with a part of your nervous system, you can have trouble moving, speaking, swallowing, breathing, or learning. You can also have problems with your memory, senses, or mood.