Daniela Vullo

Address:

University of Florence | UNIFI Dipartimento di Chimica "Ugo Schiff" Florence

Research Interests:

• Inhibition Studies
• Carbonic Anhydrases.

Biography:

1. Design and Synthesis of benzothiazole-6-sulfonamides acting as highly potent inhibitors of carbonic anhydrase isoforms I, II, IX and XII
2. Design and Validation of FRESH, a Drug Discovery Paradigm Resting on Robust Chemical Synthesis
3. Dendrimers incorporating benzenesulfonamide moieties strongly inhibit carbonic anhydrase isoforms I-XIV
4. Poly(amidoamine) Dendrimers with Carbonic Anhydrase Inhibitory Activity and Antiglaucoma Action
5. The β-carbonic anhydrase from the malaria mosquito Anopheles gambiae is highly inhibited by sulfonamides
6. Synthesis of a new series of dithiocarbamates with effective human carbonic anhydrase inhibitory activity and antiglaucoma action
7. Isoform selective inhibition of tumor-associated carbonic anhydrase IX using carbohydrate-based sulfamates for the treatment of several cancers
8. N-glycosyl-N-hydroxysulfamides as potent inhibitors of Brucella suis carbonic anhydrases
9. Cloning, characterization and anion inhibition studies of a γ-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune
10. Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune
11. Synthesis of sulfonamide conjugates of Cu(II), Ga(III), In(III), Re(V) and Zn(II) complexes: carbonic anhydrase inhibition studies and cellular imaging investigations.