Recently Published Articles
Evaluation of Direct Cost of Adverse Drug Reactions to Highly Active Antiretroviral Therapy in Indian Human Immunodeficiency Virus Positive Patients
Citation:
Vasudeva Guddattu, Noorunnisa, Sudha Vidyasagar, Radhakrishnan Rajesh,Danturulu M. Varma; Evaluation Of Direct Cost Of Adverse Drug Reactions To Highly Active Antiretroviral Therapy In Indian Human Immunodeficiency Virus Positive Patients.(2012)Open Access Pub. JCRHAP,Vol 1:Issue 1,pg no.12-22. DOI: 10.14302/issn.2324-7339.jcrhap-12-71
Abstract:
In India, interruptions to highly active antiretroviral therapy (HAART) are due to adverse drug reactions (ADRs) and no reports on the direct cost incurred in the management of ADRs to HAART are available. There is a need to study direct cost incurred with ADRs to HAART to explore the high economic cost burden imposed by ADRs to HAART in HIV/AIDS patients. This study was aimed to evaluate the direct cost incurred in the management of ADRs to HAART in Indian HIV positive patients. This prospective study was conducted at a Medicine department in a South Indian tertiary care teaching hospitals were ADRs reporting system exist. HIV-positive hospitalized in-patients were identified and intensively monitored for ADRs to HAART. The World Health Organization (WHO) probability scale was used for causality assessment of ADRs. Modified Hart wig and Siegel scale was used for severity assessment of ADRs.Pearson chi-square test identified association of mean direct cost between...
Optimization and ZSPORE Analysis of Affinity Purification Coupled with Tandem Mass Spectrometry in Mammalian Cells
Abstract:
Defining protein-protein interactions is essential for understanding the mechanisms by which cells regulate basic functions, such as metabolism, transcription, and signal transduction. Affinity purification followed by tandem mass spectrometry (AP-MS) has application for discovery of new interactors regulating various cellular processes. Here we optimize the purification method for AP-MS and develop a simplified unbiased analytical tool, Z-score plus prey occurrence and reproducibility (ZSPORE) for data analysis. Using this pipeline we achieve a higher efficiency of AP-MS and enhanced identification of high confidence interacting proteins (HCIP) in mammalian cells. When applied to analysis of the innate immune interactome, these methods enhanced HCIP identification. In addition, we investigated the GRB2 complex, which is associated with signal transduction and cell growth. Twenty-four known GRB2 interacting proteins were identified plus 26 new GRB2 binding partner...
Eukaryotic Signature Proteins
Abstract:
Eukaryotic Signature Proteins (ESPs) are proteins that delineate the eukaryotes from the archaea and bacteria. They have no recognisable homologues in any prokaryotic genome, but their homologues are present in all main branches of eukaryotes. ESPs are thus likely to have descended from ancient proteins that have existed since the first eukaryotic cell. The last dataset of ESPs was calculated more than a decade ago, thus with advances in technology and the rapid completion of many evolutionary important genomes, this dataset required recalculating. This study recalculated the Giardia lamblia ESP dataset and provides a procedure to calculate signature proteins beginning with any species. The G. lamblia ESP dataset contained a range of proteins including many associated with the membrane, cytoskeleton, nucleus and protein synthesis. ESP datasets have implications on current models of eukaryotic evolution, having high importance in phylogenetic analysis due to ESPs�...
Assessing Performance of Cattle Dung and Waste Cooked Foods in Producing Biogas as Single Substrate and Mixed Substrates in Kampala Uganda
Abstract:
Biogas is anaerobic degradation product formed from aqueous slurry of organic waste in a digester. It can be produced from cattle dung,(cd)chicken droppings, decaying leaves, kitchen waste foods(kwf), sewage sludge, slaughter house, goat, pig or sheep manure, Aqueous slurry of 200g/L of mixed or single substrate of cattle dung or/and kitchen waste evolved up to 400mL of biogas at ambient temperatures. The rate of gas evolution reached 5mL/day on the 15th day using 25% cd mixed slurry. The rates of degradation attained in the mixtures were 1.42ml/g for cd; 1.58mL/g for kwf; 1.78mL/g for 75% cd mixed substrate; 1.78mL/g for 50% cd mixed substrate; 1.92mL/g for 25% cd mixed substrate slurries. The comparative rate of biogas formation ranged from1.25 to 1.35 which was in agreement with the range published in literature of 0.8 to 5.5. Biogas can be synthesized efficiently at ambient temperature in Kampala as was done at mesophilic temperatures elsewhere. H...
Adherence to ART among Pregnant Women Living with HIV/AIDS in Lusaka Urban
Abstract:
Adherence to ART is a challenge among pregnant women living with HIV/AIDS. This has an effect on the health of the mother and the unborn child. While studies have been done, it has shown that adherence during pregnancy is a challenge Virological and clinical success depend critically on high adherence to ART because with low adherence. The success of expanded ART coverage in improving health outcomes depends on adherence to treatment. During pregnancy, a compromised Virological response to ART also increases risk of mother-to-child transmission (MTCT) of HIV. This study was carried out to determine factors that influence adherence to antiretroviral therapy among HIV positive pregnant women in Lusaka district of Zambia. This was a qualitative study which used a case study approach. Data was ...
RETRACTED: 3D-Method for Determining the Imaging Quality of Ultrasound Probes
Abstract:
Monitoring ultrasonic probe quality remains an important problem which impacts diagnostic accuracy. Here we present a quantitative method to assess probe quality primarily based on measuring probe maximum contrast (dB) and dynamic range. Contrast relevant parameters of 26 transducer models manufactured by five manufacturers were measured with a novel Random Void Phantom (RVP) approach. 3D-data were acquired and analysed to determine image quality. Acoustic contrast values ranging from 15dB to 36dB were observed. By examining artefact producing side lobes, the novel RVP approach presented here per...
Lung Cancer and Isolated Adrenal Metastases: Different Disease?
Abstract:
Distant metastases generally indicate disseminated disease and the standard treatment for these patients is palliative chemotherapy. Retrospective series showed that selected patients with metastatic lung cancer and a solitary extrathoracic disease could be effectively treated with curative intention by resection of both primary tumor and the single site of metastatic disease. According to current data, adrenalectomy might be considered as an alternative option for patients with isolated adrenal metastases. Significant morbidity and mortality may be happened by these procedures, and a cautious analysis of pros and cons should be discussed with the patient. We present a review of the literature and updated recommendations focusing lung cancer with solitary adrenal metastasis.
Growth Performance of Heteroclarias Juveniles Fed Graded Levels of Autoclaved Castor Seed (Ricinus communis L.) Cake Based Diets
Abstract:
An 84 day feeding trial was conducted on the juveniles (42.51±0.09g) of hybrid catfish,