Journal of Fertility Biomarkers

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Fertility Biomarkers-Sperm quality-Donald Evenson

United States

President and Director,
SCSA Diagnostics and Adjunct Professor,
Sanford Medical School, USD.

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Donald Evenson


SCSA Diagnostics,
302 6th St. W, Suite B,
Brookings, SD 57006,
United States.

Research Interests:

  • Sperm quality
  • Sperm DNA
  • Sperm cell differentiation
  • Sperm Chromatin


  • Dr. Evenson received his Ph.D. from the University of Colorado in Cell Biology, and received an appointment at the Sloan Kettering Cancer Research Institute at Cornell University before completing a post-doctoral position at Florida State University’s Institute of Molecular Biophysics. In 1986, 
  • Dr. Evenson founded SCSA Diagnostics, revolutionizing the field of DNA damage testing by commercializing a test for sperm DNA integrity, which is still widely used by fertility clinics around the world. 
  • This assay uses flow cytometry to measure DNA fragmentation, or the incidence of double strand breaks in the DNA in sperm cells, which is reported as a DNA Fragmentation Index, or %DFI. 
  • This test has been instrumental in providing clinics around the world with access to DNA integrity testing, as it does not have to be done on-site with a standard semen analysis. 
  • Headquartered in South Dakota, SCSA Diagnostics also has affiliated testing centers in Brazil, France, England, Sweden, the Czech Republic, India, and Australia. 
  • Dr. Evenson has become an advocate for sperm DNA testing in all couples struggling with fertility, insisting that even with a normal semen analysis, sperm DNA may be compromised.
  • Dr. Evenson has served as an adjunct professor at both Oregon State University and the Department of Obstetrics and Gynecology at Sanford Medical School at the University of South Dakota. 
  • He is active in several international professional societies, including the American Society of Reproductive Medicine, the American Association of Bioanalysts, the American Society of Andrology, the European Society of Human Reproduction and Embryology, Sigma Xi, and the Environmental Mutagen Society. 
  • In addition to the development of DNA integrity diagnostics.
  • Dr. Evenson’s research has included establishing links between age, environmental exposure, sperm DNA integrity, and reproductive risk. 
  • He has also dedicated much of his work to generating evidence that DNA damage is associated with poor outcomes after the use of Assisted Reproductive Techniques (ART).