All Articles

Design Support to steer Creative Wicked Problem Solving Processes with Knowledge Management and Artificial Intelligence

Abstract:

As the complexity of building tasks and requirements increases, designers often find themselves confronted with interdisciplinary problems that go beyond the specific challenges and methods of architecture. The iterative nature of the design process results in a continuous exchange between creative, analytical and evaluative activities, through which the designer explores and identifies promising design variants. The ability to compare and evaluate relevant reference examples of already built or designed buildings helps designers to assess their own design and informs the design process.

Construction of Virtual Neuron and Consolidation of Sleep and Memory Process– A Molecular Docking and Biomathematical Approach

Abstract:

This methods paper combines molecular docking and biomathematical modeling to construct a virtual neuron framework for studying sleep‑related memory consolidation. It outlines model components and validation approach.

Lung Cancer and Isolated Adrenal Metastases: Different Disease?

Abstract:

Distant metastases generally indicate disseminated disease and the standard treatment for these patients is palliative chemotherapy. Retrospective series showed that selected patients with metastatic lung cancer and a solitary extrathoracic disease could be effectively treated with curative intention by resection of both primary tumor and the single site of metastatic disease.

According to current data, adrenalectomy might be considered as an alternative option for patients with isolated adrenal metastases. Significant morbidity and mortality may be happened by these procedures, and a cautious analysis of pros and cons should be discussed with the patient.

We present a review of the literature and updated recommendations focusing lung cancer with solitary adrenal metastasis.

Molecular Composition of and Potential Health Benefits Offered by Natural East African Virgin Sunflower Oil Products: A 400 MHz 1H NMR Analysis Study

Abstract:

Sunflower oil (SFO) is regularly employed for cosmetic, emollient and food frying purposes, the latter representing its foremost use globally. Therefore, full investigations of the molecular composition and quality of SFO products are a major requirement. In this study high-field ¹H NMR analysis was employed to explore the molecular composition and authenticities of East African virgin (EAV) SFO products, particularly their acylglycerol fatty acid contents, together with those of selected minor constituents. Results acquired were statistically compared to those obtained on commercially-available, EU-approved refined SFO products via NMR-linked multivariate chemometrics strategies.

Diaphragmatic Pacing as an Alternative to Mechanical Ventilation: Early Experience from a Developing Country

Abstract:

The aim of this study is to evaluate the outcomes of patients submitted to diaphragmatic pacing, and the impact on quality of life of patients who chronically depend on mechanical ventilation, as well as the effectiveness of phrenic stimulation to eliminate the need for mechanical ventilation.

Purification and Characterization of Xanthine Oxidase from Liver of the Sheep (Ovis Aries)

Abstract:

Xanthine oxidase is a commercially important enzyme with wide area of medical applications to develop diagnostic kits. Xanthine oxidase was extracted, purified and characterized from sheep liver (SLXO). The purification procedure involved acetone precipitation and chromatography on DEAE-cellulose and Sephacryl S-300 columns. The sheep liver xanthine oxidase was homogeneously purified 31.8 folds with 3.5 U/mg specific activity and 24.1% recovery. SLXO native molecular weight was 150 kDa and on SDS-PAGE appeared as single major band of 75 kDa representing a homodimer protein. Isoelectric focusing of the purified SLXO resolved into two closely related isoforms with pI values of 5.6 and 5.8. The apparent Km for xanthine oxidase at optimum pH 7.6 was found to be 0.9 mM xanthine. FeCl₂ and NiCl₂ increased the activity of SLXO, while CuCl₂ and ZnCl₂ were found to be potent inhibitors of the purified en...

The use of Dermacell® in Fingertip Injury

Abstract:

Matrices or tissue scaffolds provide a collagen structure for tissue remodelling while the removal of viable cells aims to minimize or prevent inflammatory or immunogenic response.

Allograft collagen scaffold can support the patient’s own cellular ingrowth, ingeneered to minimize an immune response and to yeld a bio-compatible matrix and support incoming cellular growth. The decellyularized dermis retains its growth factors, native collagen scaffold, and elastin, thanks to a LifeNet Health proprietaryprocessin technology.

Asymptomatic Embolization After Percutaneous Ostium Primum Atrial Septal Defect Closure: a Rare Complication

Abstract:

Percutaneous device closure of atrial septal defects (ASD) has proven to be safe and it is nowadays the standard treatment for ASDs. Immediate or late device embolization is a rare but potential complication of every attempted ASD device closure. We report a case of asymptomatic Amplatzer Septal Occluder into the left ventricular outflow tract (LVOT) detected by routine transthoracic echocardiography 3 months after successful implantation in a stable patient.

Misoprostol (Cytotec) for Prevention of Ovarian Hyperstimulation Syndrome. A Preliminary Investigation.

Abstract:

This preliminary study explores misoprostol as a preventive strategy for ovarian hyperstimulation syndrome. It outlines rationale, dosing considerations, and early safety signals, and calls for controlled trials to establish efficacy and risk–benefit.

Acute Pneumonia: Biological Rules and Laws require Attention and Respect.

Abstract:

A perspective argues that biological rules and host–pathogen dynamics deserve greater attention in pneumonia care. It integrates pathophysiology with clinical decision‑making.