All Articles

Neuroscience Theories, Hypothesis and Approaches to ASD Physiopathology. A Review

Abstract:

According to the results of our laboratory the theory of immune dysfunction, the theory on the genetic architecture of ASD, the disrupted cortical connectivity theory and the theory on the contribution of cerebellum to ASD have shown fundamental experimental evidences to support the core symptoms of the complex and enigmatic physiopathology of autism spectrum disorder. The additional hypothesis about the neurogenesis in the amygdala, the contribution of oxytocin, vasopressin, the mirror neuron network, and mitochondrial dysfunction described are stimulating and interesting approaches that deserve further systematic basic and clinical neuroscience research.

Allele Based Inference on Evolution and Extinction; A Genetic Drift Approach

Abstract:

In other to present a series of stochastic models from population dynamics capable of describing rudimentary aspects of genetic evolution, we studied two-allele Wright–Fisher and the Moran models for evolution of the relative frequencies of two alleles at a diploid locus under random genetic drift in a population of fixed size “simplest form, selection, and random mutation”. Principal results were presented in qualitative terms, illustrated by Monte Carlo simulations from R and http://www.radford.edu/~rsheehy/Gen_flash/popgen. Moran and the Wright-Fisher Models exhibited the same fixation probabilities, only that the Moran model runs twice as fast as the Wright-Fisher Model. A clue that can help us to understand this result is provided by the variance in reproductive success in the two models. Genetic changes due to drift were neither directional nor predictable in any deterministic way. Nonetheless, genetic drift led to evolutionary change in the absence of...

In VivoEvaluation of the Protective Capacity of Different Gloves Against Hair Dyes

Abstract:

Hairdressers are taught to use gloves when dyeing hair. We wanted to study what gloves are recommendable for other common hair dye substances than p-phenylenediamine, such as toluene-2,5-diamine sulphate and 2‐methoxymethyl‐p‐phenylenediamine. The gloves used in professional salons and the gloves commonly sold with hair dyes for home-use were investigated. 7 volunteers previously allergic to toluene-2,5-diamine sulphate and p-phenylenediamine were tested in vivo with an open chamber test system to examine the permeation of chemicals through gloves (vinyl, nitrile and polyethylene), mimicking the real use condition of permanent hair dyes. The nitrile gloves used gave excellent protection with all four hair dyes tested. A good capacity of protection was found with the polyethylene glove, supplied with the package of a home-use hair dye, whe...

A Meningeal Syndrome Revealing A Tetanus in A Togolese: Case Report and Review of the Literature

Abstract:

Although it is a vaccine-preventable disease, tetanus is frequently found in sub-Saharan Africa. Because of its rarity, this disease poses two problems for doctors of the 21st century: to make early diagnosis in order to refer patients to appropriate care structures, and to continue to ensure correct prevention of an affection that few current doctors have met. In it generalized form, the diagnosis of tetanus is easy, but when the beginning is localized, tetanus can be change with other diseases leading to a diagnostic wandering and a delay of adequate management. We report a case of tetanus in an 18-year-old male, who was received for neck pain and stiffness of the neck with a positive Kernig sign associated to fever since 48 hours. Initially treated for meningitis, the patient will develop at day 3 of hospitalization, the signs of generalized tetanus which led to evoked the diagnosis of tetanus. This diagnosis was reinforced by the notion of a rusty nail injury ...

Using a Medication Plan as a Quality Indicator: Feasibility and Satisfaction Results from an Observational Study

Abstract:

Medication adherence remains a challenge for patient management. Changes in the drug regimen after a hospital stay can lead to confusion or misunderstandings. We implemented a structured patient-centered interview during which a computer-generated individualized medication plan was discussed and provided to patients at discharge.

Alpha-Fetoprotein and its Receptor: More Than Oncofoetal Antigens.

Abstract:

This review revisits alpha‑fetoprotein (AFP) and AFP receptor biology beyond their classic role as oncofetal markers. It summarizes signaling, tumor biology, and clinical implications across malignancies, including diagnostic, prognostic, and therapeutic angles. The authors highlight opportunities and limitations for AFP‑targeted interventions.

Modified Direct Transfer Coping Technique for Making Impression of Closely Placed Implants

Abstract:

The main purpose of the impression is to record and transfer the relationship between implants and to reproduce this relationship as accurately as possible. But, Unplanned placement of the implants may result in close approximation of the implants, thereby posing tough challenge to the restorative dentist, to first accurately record the impression and later on fabricate the prosthesis with satisfactory esthetics and function. This article presents a modified direct impression coping procedure for precise making of impression of closely placed implants which otherwise may be difficult to replicate the exact position of the implants by conventional direct or indirect technique.

Severe Vitamin D Deficiency in Saudi Patients with Type 2 Diabetes Mellitus

Abstract:

It has been demonstrated that vitamin D deficiency is associated with type 2 diabetes mellitus (T2DM). We conducted a cross sectional study to investigate the prevalence severe vitamin D deficiency in patients with T2DM.

Rosenthal's Disease (Hemophilia C or factor XI Deficiency) Revealed by Chronic Epistaxis: The First Observation in Sub-Saharan Africa.

Abstract:

Rosenthal's disease (RD) is a rare constitutional hemorrhagic disorder defined by factor XI deficiency. It is clinically characterized by the presence of minimal haemorrhage. We report the first observation of RD in Togo.

Ultraviolet B Phototherapy Intervention in Patients with Multiple Sclerosis: A Prospective, Randomized Pilot Trial

Abstract:

There is substantial evidence, from well-conducted epidemiological studies, that low vitamin D levels are correlated with increased risk for MS, and multiple case control studies have implicated the involvement of vitamin D deficiency in MS etiology. Narrow-band Ultraviolet B (NB-UVB; 300nm - 311 nm) induced vitamin D production has not previously been studied in a multiple sclerosis (MS) randomized placebo-controlled trial (RCT).