Louisiana State University,
Health Sciences Center-New Orleans.
1901 Perdido Street,
New Orleans, LA 70112,
- Dr. Simon’s research interests are to understand the signaling mechanisms responsible for proliferation and differentiation of stem/progenitor cells and perturbations that alter stem cells and its microenvironment affecting the fate of cells.
- The laboratory is specifically interested in dysregulation of skeletal muscle stem cell (satellite cells) signaling that alters the fate of these cells. Using a model of chronic alcohol and Simian Immunodeficiency Virus (SIV) infection, Dr. Simon is studying the molecular mechanisms of impaired differentiation of satellite cells.
- The research is in collaboration with eminent LSUHSC researchers in the field of alcohol and SIV
Currently two mechanisms are being investigated:
- Does a chronic proinflammatory and prooxidative skeletal muscle milieu inhibit myogenesis.
- Does an altered skeletal muscle milieu induce epigenetic alterations in satellite cells leading to impaired myogenesis?
- Dr. Simon received her Ph.D. in endocrine physiology with the support of an Indian Council of Agricultural Research fellowship and did her postdoctoral training at the College of Veterinary Medicine, University of Illinois at Urbana Champaign in stem cell/endocrine physiology.
- She was an Assistant Professor in the Department of Biomedical Sciences at the College of Veterinary Medicine, Tuskegee University from 2010-2013.
- She also held an adjunct faculty position, Department of Pathology, School of Medicine at the University of Alabama at Birmingham from 2012-2013.
- She joined the Department of Physiology at LSUHSC, NO in July 2013.