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Journal of Aging Research and Healthcare

Current Issue Volume No: 2 Issue No: 4

ISSN: 2474-7785
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Review Article Open Access
  • Available online freely Peer Reviewed
  • Haematuria in the Elderly: a Review

    Yvonne Dabota Buowari 1  

    1New Jerusalem Road, Bonny, Rivers State, Nigeria


    Haematuria is a common compliant in the elderly. Microscopic haematuria is first suspected after a dipstick in urine and confirmed with urine microscopy. The causes of haematuria in the elderly may be renal or extra-renal including clotting disorders. This article is a review on haematuria in the elderly.

    Author Contributions
    Received 06 Jun 2019; Accepted 18 Jun 2019; Published 23 Jun 2019;

    Academic Editor: Ian James Martins, Edith Cowan University, Australia.

    Checked for plagiarism: Yes

    Review by: Single-blind

    Copyright ©  2019 Yvonne Dabota Buowari

    Creative Commons License     This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

    Competing interests

    The authors have declared that no competing interests exist.


    Yvonne Dabota Buowari (2019) Haematuria in the Elderly: a Review. Journal of Aging Research And Healthcare - 2(4):7-10.

    Download as RIS, BibTeX, Text (Include abstract )

    DOI 10.14302/issn.2474-7785.jarh-19-2932


    Aging is a physiological process that causes changes in many organs in the body including the kidneys with subsequent structural and functional changes. For these reasons the elderly are more likely to develop kidney diseases that may present with haematuria1. Haematuria is the presence of red blood cells in urine2 and it is a common symptom of patients in primary care practice3. It may be the only symptom of a disease condition or there may be other associated symptoms4. Haematuria in the elderly is a sign of an underlying disease which may be benign or malignant5. The definitive diagnosis of haematuria is made following microscopic examination of the urine except where the haematuria is visible to the naked eyes. There are various definitions for haematuria. Haematuria may be a symptom of urinary tract infection and it may be macroscopic or microscopic. Taking regular doses of aspirin could be a potential cause of microscopic haematuria in the elderly. The prevalence of microscopic haematuria in a study by Moudi et al was 27.27% in regular users of aspirin6. The prevalence of microscopic haematuria in this study was significantly higher among the regular users of aspirin compared to non-users.

    Types of Haematuria in the Elderly

    The types of haematuria in the elderly are the same as haematuria in the general population. There are basically two types of haematuria namely:

    1. Gross or Macroscopic Haematuria: The haematuria is visible to the naked eyes in macroscopic haematuria.

    2. Microscopic Haematuria: This is when the haematuria is not visible to the naked eyes. There are various definitions for making a diagnosis of microscopic haematuria from different authorities. The American Urological Association defines microscopic haematuria as three or more red blood cells per high power field (HPF) on microscopic analysis of two or three properly collected urine specimens4,5, the Canadian Urological Association (CUA) defines it as greater than two red blood cells per high power field (RBC/HPF) on two separate urinalysis in the absence of exercise, menses, sexual activity or instrumentation4. The initial suspicion for microscopic haematuria is made by using a dipstick. It is the confirmed with microscopy of the urine7. The urine shall be freshly voided and the patient should not have any form of sexual activity, exercise and instrumentation of the genitourinary system.

    Causes of Haematuria in the Elderly

    Haematuria in the elderly is caused by a vast number of causes arising either from the urinary system or elsewhere. It may be a sign of disease of the genitourinary system or non-urologic disease8. Therefore blood in the urine is a sign of an underlying condition and should be investigated thoroughly9. Haematuria may arise from any part of the urinary tract2. The causes of haematuria in the elderly are:

    1. Urinary tract infection including schistosomiasis.

    2. Malignancies of the urinary tract. This includes malignancy of the bladder, urethra, ureter, kidneys. Malignancies of the urinary tract usually present with macroscopic haematuria, 88% with bladder cancers and 40% with renal cancer4. Macroscopic haematuria may be the only sign of a malignancy of the genitourinary system7.

    3. Ureteric and renal stones

    4. Nephropathies

    5. Benign prostatic hyperplasia

    6. Radiation induced cystitis

    7. Clotting disorders such as haemophilia

    8. Inflammation of the kidney, urethra, bladder or prostrate

    9. Drug induced haematuria: Some drugs that can induce haematuria3 are:

    a. Cyclophosphamide

    b. Amitriptyline,

    c. Rifampin,

    d. Non-Steroidal Anti-Inflammatory Drugs

    Haematuria that is intractable may be caused by radiation cystitis, carcinoma of the bladder, and cyclophosphamide induced cystitis10. False haematuria may arise from food pigments, drug metabolites and malingering2. In some cases, there is no identifiable cause of the haematuria. This may be from transient benign physiological conditions, vigorous physical exercise and sexual intercourse7.

    Management of Haematuria in the Elderly

    Management of haematuria in the elderly involves taking a comprehensive history, physical examination, conducting investigations and drugs. Sometimes blood may be required.

    History Taking

    Haematuria may be the only presenting compliant especially when it is macroscopic or in association with other symptoms like fever, nausea and vomiting. It may also be incidental finding when screening for other diseases or routine screening especially if it is microscopic The history should include detailed history concerning genitourinary symptoms such as:

    1. Frequency

    2. Incontinence

    3. Change in the character of the urine stream9

    4. Pain

    a. Dysuria: Macroscopic haematuria that is painless is likely due to malignancy of the genitourinary tract13.

    b. Abdominal pain: Nature of the pain if it is dull or sharp and also its location.

    5. Urgency

    6. If there are no other symptoms

    7. If it is episodic or continuous

    8. During urination if the haematuria initial, terminal or total

    9. Periorbital and pedal oedema

    10. Use of nephrotoxic drugs medications

    11. Co-morbidity

    12. Family history of coagulation disorders and renal diseases

    13. Passage of stones, tissues and clots

    Physical Examination

    General Physical Examination is Done

    1. Checking for pallor

    2. Check for edema, periorbital edema and pedal edema

    3. Blood pressure measurement

    4. Examination of the cardiovascular system

    5. Examination of the urinary system

    6. Abdominal examination

    Symptoms of diseases of the lower urinary tracts are common in the elderly12.

    Investigations for the Elderly Presenting with Haematuria7,12

    1. Urine tests: urine microscopy, culture and sensitivity

    2. Blood tests:

    a. full blood count, serum, urea and creatinine

    b. Kidney function tests including glomerular filtration rate

    c. Clotting profile

    d. Whole blood or blood products if available should be cross matched and saved for macroscopic haematuria depending on the state of pallor/anaemia and also the cardiovascular stability of the patient.

    e. Prostate specific antigen for males

    When the creatinine is elevated and there is proteinuria, it signifies that the haematuria is likely from a medical disease.

    3. Radiological Imaging

    a. Abdominal ultrasonography

    b. Computed tomography scan (CT-Scan)

    c. Magnetic resonance imaging

    d. Intravenous pyelogram

    In the management of haematuria, imaging of the urinary tract, urine cytology and cystoscopy are necessary as some small cancers may not be visible on some imaging techniques11,12.

    Management of Haematuria in the Elderly

    The management of haematuria is dependent on if it is macroscopic or microscopic, and also on the cause of the haematuria if it is known. Microscopic haematuria can be managed on an out-patient basis. In macroscopic haematuria, the patient should be resuscitated13 and blood transfusion or blood products are transfused when necessary. Macroscopic haematuria may be managed as an out-patient depending on the quantity of blood lost and cardiovascular stability of the patient. The patient should be encouraged to drink enough fluid to remain hydrated. Free drainage of urine should be ensured with or without a urinary catheter in-situ. The patient should be followed up after discharge to monitor any reoccurrence especially if the haematuria was caused by a malignancy. The cause of the haematuria should be identified and treated. Macroscopic haematuria is a common presentation seen in the emergency room13. The indications for in-patient management of haematuria in the elderly are clot retention, cardiovascular instability, uncontrolled pain, sepsis, acute kidney injury, coagulopathy, severe comorbidity, and social restriction13.


    Haematuria which is the presence of red blood cells in urine in the elderly has been highlighted in the article. It can be microscopic or macroscopic. There are several causes of haematuria in the elderly. Investigations to be done include blood tests, urine tests, and imaging of the urinary tract. The definitive treatment depends on the cause of the haematuria although sometimes the cause is unknown.


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    7.Yeoh M, Lai N K, V Anderson D Appadurai. (2013) Macroscopic Haematuria , A Urological Approach, Evolution Of General Practice. 42(3), 123-126.
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    9.Patel J V, Chamber C V, Gomella L G. (2008) Haematuria: Etiology and Evaluation for the Primary Care Physician. , Can J Urol,(S1)5: 54-62.
    10.SKS Choong, Walkden M, Kirby R. (2000) The Management of Intractable Haematuria. , BJU International 86, 951-959.
    11.Juthani-Mehta M.Chapter 32: Urinary Tract Infections in The Elderly Persons. Geriatric Nephrology. 1-4.
    12.Dyche D, Hollander J.Chapter 31: Lower Urinary Tract Conditions in Elderly Patients. , American Society of Nephrology. Geriatric Nephrology Curriculum 1-5.
    13.Hicks D, Li C. (2007) Management of Macroscopic Haematuria in the Emergency Department. Emerg Med J. 24(6), 385-390.

    Cited by (2)

    1.Mahmudiono Trias, Zebadia Eurika, Setyawati Utari Gita, Sahila Nur, Nathania Devina Amelinda, et al, 2023, Urine analysis and nutrition status among elderly in Griya Werdha, Surabaya, Journal of Public Health in Africa, (), 10.4081/jphia.2023.2563
    2.Chhong Lay Ngeab, Poovorawan Kittiyod, Hanboonkunupakarn Borimas, Phumratanaprapin Weerapong, Soonthornworasiri Ngamphol, et al, 2020, Prevalence and clinical manifestations of dengue in older patients in Bangkok Hospital for Tropical Diseases, Thailand, Transactions of The Royal Society of Tropical Medicine and Hygiene, 114(9), 674, 10.1093/trstmh/traa043