Jari Koistinaho

Address:

Biomedicum 1 Haartmaninkatu 4 00014 Helsingin yliopisto

Research Interests:

CNS cytokines, inflammation, neurodegeneration, iPSC derived models

Biography:

Publications:

1. Sulfosuccinimidyl oleate sodium is neuroprotective and alleviates stroke-induced neuroinflammation.
2. Retinal Degeneration in A Mouse Model of CLN5 Disease Is Associated with Compromised Autophagy.
3. DHCR24 exerts neuroprotection upon inflammation-induced neuronal death.
4. PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease.
5. Disease-Induced Alterations in Brain Drug Transporters in Animal Models of Alzheimer’s Disease.
6. Loss of CLN5 causes altered neurogenesis in a childhood neurodegenerative disorder.
7. Human Ipsc-Derived Alzheimer’s Disease Astrocytes Recapitulate Disease-Related Phenotypes.
8. Collagen XIII secures pre- and postsynaptic integrity of the neuromuscular synapse.
9. Lack of collagen XV is protective after ischemic stroke in mice.
10. The Copper bis(thiosemicarbazone) Complex CuII(atsm) Is Protective Against Cerebral Ischemia Through Modulation of the Inflammatory Milieu.
11. ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis.
12. Perineuronal nets in neurodegeneration.
13. Bexarotene targets autophagy and is protective against thromboembolic stroke in aged mice with tauopathy.
14. Nontargeted Metabolite Profiling of Induced Pluripotent Stem Cells (iPSCs) Derived Neural Cells: Insights Into Mechanisms of Brain Diseases.
15. Metabotropic glutamate receptor 5 responses dictate differentiation of neural progenitors to NMDA-responsive cells in fragile X syndrome: mGluR5 in human and mouse fragile X progenitors.
16. Creation of a library of induced pluripotent stem cells from Parkinsonian patients.