Protein-Protein Complexes

Overview

Protein-protein complexes are assemblies formed when two or more proteins interact through specific, structurally defined interfaces to carry out biological functions that the individual proteins cannot perform alone. These interactions may be stable and obligate, as in multi-subunit Enzymes and structural assemblies, or transient and regulatory, as in signalling and the dynamic recruitment of partners. Complex formation underlies enzyme catalysis and allosteric regulation, the relay of signals between and within cells, the control of gene expression, and the maintenance of cellular architecture. The specificity and stability of a complex depend on the chemistry of its interface, including hydrogen-bonding networks, hydrophobic contacts, electrostatic interactions, and covalent links such as disulfide bonds that can mediate dimerization and DNA binding. Research relevant to this field includes the role of hydrogen-bonding networks in shaping the catalytic activity and diversity of Enzymes such as chloroperoxidase, the use of affinity purification coupled with tandem mass spectrometry to isolate and identify interacting proteins, and the analysis of protein domain conservation and architecture across lineages. Proteomic and genomic techniques provide the means to map interactions on a large scale and to characterize how complexes assemble and function. Study of protein-protein complexes spans the structural and energetic basis of molecular recognition, the experimental methods used to detect and characterize interactions, and the role of these assemblies in enzymatic activity, signalling, and the broader organization of cellular processes.

Research published in this journal

9 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 9 articles above have been cited 29 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

• Genome-wide characterization of BPC transcription factors in pear and functional validation of PbBPC5 in drought tolerance regulation
  2026 · Frontiers in Plant Science
• GENOME-WIDE IDENTIFICATION AND CHARACTERIZATION OF PLANT SPECIFIC BPC TRANSCRIPTION FACTOR GENE FAMILY IN COTTON
  2026 · Bulletin of Biological and Allied Sciences Research
• A comprehensive genome-wide analysis for signatures of selection in goat (genus Capra) revealed new candidate genes for environmental adaptation and productive traits
  2025 · BMC Genomics
• Genome-wide identification of flowering Chinese cabbage BPC family genes and BcBPC9 functional analysis in Cd stress tolerance
  Shuai Zhang et al. · 2023 · Plant Stress
• Plant BBR/BPC transcription factors: unlocking multilayered regulation in development, stress and immunity
  A. Sahu et al. · 2023 · Planta
• Plant BBR/BPC transcription factors: unlocking multilayered regulation in development, stress and immunity
  2023 · Planta
• Genome-wide identification of flowering Chinese cabbage BPC family genes and BcBPC9 functional analysis in Cd stress tolerance
  2023 · Plant Stress
• Coping with Drought: Consequences, Responses, and Plant Growth Promoting Rhizobacteria Mediated Amelioration Mechanisms in Crop Plants
  2023 · Gesunde Pflanzen

A sample of recent works citing this journal's research on Protein-Protein Complexes, linking to each citing work.

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