Research Topic · Peer-Reviewed

Adenosine

Adenosine is a purine nucleoside formed from the nitrogenous base adenine joined to a ribose sugar through an N-glycosidic bond. It occupies a central position in cellular biochemistry as the structural core of the adenine nucleotides—adenosine triphosphate (ATP), adenosine diphosphate (ADP), and adenosine monophosp…

Curated from this journal's research 📚 11 peer-reviewed articles cited Cited 29× across the literature 🔖 ISSN 2690-4829 🗓 Reviewed July 2026

Overview

Adenosine is a purine nucleoside formed from the nitrogenous base adenine joined to a ribose sugar through an N-glycosidic bond. It occupies a central position in cellular biochemistry as the structural core of the adenine nucleotides—adenosine triphosphate (ATP), adenosine diphosphate (ADP), and adenosine monophosphate (AMP)—as well as the second messenger cyclic AMP, and it is incorporated into the backbone of nucleic acids. Beyond its metabolic and structural roles, adenosine acts as an extracellular signaling molecule through specific G-protein-coupled adenosine receptors. Its concentration is governed by a network of Enzymes: adenosine is generated by the dephosphorylation of AMP and is removed principally by adenosine deaminase, which converts it to inosine and feeds into the purine-degradation pathway. Further catabolism proceeds through hypoxanthine and xanthine to uric acid, a reaction catalyzed by xanthine oxidase. Physiologically, adenosine mediates coronary and systemic vasodilation, modulates neuronal activity—an effect competitively antagonized by caffeine and related methylxanthines—and influences platelet aggregation. Deficiency of adenosine deaminase causes severe immunodeficiency, while synthetic nucleoside analogues derived from the adenosine scaffold, including fluorinated and halogenated congeners, serve as antiviral and anticancer therapeutics, underscoring the enzymatic and pharmacological importance of this nucleoside.

Research published in this journal

11 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2020

Caffeine Components Empower the Brain Potentiality

Nasim Habibzadeh SeyedehCorresponding author
PhD student in Sport Science, School of Health and Life Sine, Department of Sport Science, Teesside University, United Kingdom
Exact topic Spine and Neuroscience doi:10.14302/issn.2694-1201.jsn-20-3523

How this research is being cited

The 11 articles above have been cited 29 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Adenosine, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Enzymes (ISSN 2690-4829).

Journal editorial board
Loredana Marcolongo · Italy Melike Caglayan · United States Daniela Vullo · Italy

This page summarises published research for orientation; it is not medical or professional advice.