Antioxidants and aging-related diseases concerns the role of redox-active compounds in the chronic conditions whose incidence rises with age, including cardiovascular disease, neurodegenerative disorders such as Alzheimer's and Parkinson's disease, certain cancers, and degenerative conditions like age-related macula…
Antioxidants and aging-related diseases concerns the role of redox-active compounds in the chronic conditions whose incidence rises with age, including cardiovascular disease, neurodegenerative disorders such as Alzheimer's and Parkinson's disease, certain cancers, and degenerative conditions like age-related macular degeneration. A long-standing framework, the free-radical or oxidative-stress theory of aging, holds that cumulative damage to lipids, proteins, and DNA from reactive oxygen species contributes to cellular senescence and tissue decline, with phenomena such as oxidative telomere attrition linking redox status to biological aging. Antioxidant defenses relevant here span enzymatic systems including superoxide dismutase, catalase, and glutathione peroxidase, and exogenous antioxidants such as vitamins C and E, carotenoids, selenium, and dietary polyphenols and flavonoids. Research investigates how these molecules modulate oxidative damage, inflammation, and redox signaling associated with age-related pathology, frequently screening plant extracts and characterizing them through radical-scavenging assays, total phenolic and flavonoid content, and total antioxidant capacity. A central and contested scholarly question is whether antioxidant supplementation slows aging or its associated diseases, given that broad clinical trials have often been inconclusive; this has redirected attention toward dietary patterns, hormesis, bioavailability, and the distinction between harmful oxidative damage and physiologically necessary redox signaling.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 66 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Antioxidants and Aging-related Diseases, linking to each citing work.