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The Daughter of Time: Late Development of Waldenstrom’s Macroglobulinemiain a Patient with Immunotactoid Glomerulopathy.

Abstract:

Immunotactoid glomerulopathy (ITG) is a rare cause of chronic kidney disease (CKD) and end-stage-renal-disease (ESRD). It is often associated with monoclonal gammopathy and/or hematologic malignancy. We report a patient originally diagnosed with ITG in 1998. He presented with nephrotic-range proteinuria, hypertension, and a gradual decline in glomerular filtration rate. A published case report of this patient at the time the disease was originally diagnosed described only a small peak of IgM paraprotein without lymphoma or plasma cell dyscrasia. He was diagnosed with monoclonal gammopathy of unknown significance. He later developed ESRD and initiated hemodialysis in 2004. Fourteen years after the diagnosis of ITG and MGUS was made he developed headache, lymphadenopathy, borderline splenomegaly, thrombocytopenia, and coagulopathy. Workup revealed a very high level of monoclonal IgM-kappa (4390 mg/dL),and low grade B-cell lymphoma, consistent with lymphoplasmacytic ...

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The Total Antioxidant Capacity of Foods: A Reappraisal. Application to Commercial Orange Juices

Abstract:

Since a few years, more and more attention has been specifically given to dietary antioxidants as agents promoting health and preventing the incidence of diseases. As part of these efforts, analytical methods and assays have been developed to measure the antioxidant content in food substances. In this paper, the antioxidant capacity of 17 orange juices is determined by various assays (DPPH, ORAC, heamolysis, xanthine/xanthine oxidase) as the content in ascorbic acid and total phenolics. The results evidence all the complexity to evaluate the in vitro antioxidant capacity of foods. In very general terms, in spite of the wide utilization in these tests (FRAP, TAC, ORAC TRAP and others), their significance remains obscure. The discrepancy of the results and the absence of good correlation between the assays clearly highlight all the importance of understanding the strengths and weakness of assays evaluating antioxidant potential of a food at the risk...

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Contact Hypersensitivity to Lavender Oil in Hungary: A Multicentre Survey 2013-2014

Abstract:

Background:

Lavender has been used for centuries, but its exposure has become part of the everyday life in our days. It is used in the alternative medicine, and as a flavouring component in soaps, cosmetics and in food products (chocolate, ice-cream, spices). The increasing number of exposures resulted the appearance of hypersensitivity- reactions.

Objectives:

A survey on the prevalence of lavender hypersensitivity was conducted by the Contact Dermatitis Work-Group of the Hungarian Dermatological Society in a multicentre, prospective study.

Patients and Methods:

1509 consecutivedermatological patients of 7 dermatological centres were involved in this study. Results were based on the anal...

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Evolution in Scientific Production in the Area of Vegetarian Nutrition, 1907-2013.

Abstract:

The objective is to evaluate the scientific evolution of articles about vegetarian nutrition. We analyzed the publication of articles of vegetarian nutrition, using the key term ‘vegetarian’ in the National Institutes of Health MEDLINE bibliographic database between 1907 and 2013. We quantified the number of articles in vegetarian nutrition by 5–y time periods, and we classified the kind of journals, the affiliation of the first author, the origin of the study population and the type of articles. The number of articles found in MEDLINE is 3256. The publication rate of vegetarian articles increased steadily, except in periods of 2006-2010 and 2011-2013, and this was explained because the application of “embargo period” for the some publishers. Non-nutrition journals have published more articles on vegetarian nutrition for all periods. It is observed that after 1960 the articles on vegetarian nutrition are proportionately greater than the total published, ...

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Ocular Manifestations of Vitamin A Deficiency Among the Rural Pre-School Children of North India

Abstract:

Purpose:

Vitamin A deficiency (VAD) is still a major nutritional problem of public health importance among the rural pre-school children in India, even after the implementation national vitamin A prophylaxis programme for prevention of nutritional blindness and ICDS have been in operation for more than three decades. The purpose of this communication is to assess the prevalence of ocular manifestations of vitamin A deficiency among rural pre-school children of north India.

Methods:

A community based cross-section study; adopting multi-stage random sampling procedure was carried out by NNMB among rural pre-school children of four north Indian states viz. Maharashtra, Madhya Pradesh, Orissa and West Bengal. A total of 36,111 rural pre-school children of 1-5years (Boys: 18408; Girls: 17703) were covered for this study.<...

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Radical-Scavenging and Anti-Oxidative Activities of TBN in Cell-Free System and Murine H9c2 Cardiomyoblast Cells

Abstract:

Reactive oxygen species (ROS) and reactive nitrogen species are believed to be one of the most important culprits in the pathogenesis of cardio/cerebrovascular diseases. Intensive researches have been conducted to target free radicals as potential treatment for cardio/cerebrovascular diseases. The 2-(((1,1-dimethylethyl) oxidoimino)-methyl)-3,5,6-trimethylpyrazine (TBN), a novel nitrone derivative of tetramethylpyrazine, has been demonstrated to exhibit significant therapeutic effects in ischemic stroke and Parkinson’s models due to its multiple functions, including calcium overload blockade and free radical-scavenging activity. In the present study, we found that TBN had significant radical trapping effect in cell-free assays. Additionally, TBN effectively blocked tert-butylhydroperoxide (t-BHP)-induced murine H9c2 cardiomyoblast cell death, suppressed H9c2 cell apoptosis and reversed the decrease in mitochondrial membrane pote...

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Clinical and Immunological Beneficial Effects of Phyto V7 Consumption by HIV-1 Seropositive Individuals

Abstract:

Phytochemicals (PHT) are a large group of biologically active plant chemicals that may have positive effects on human health such as immune system stimulation, down regulation of inflammatory responses, radical scavenging activities, cell repair function, and antibacterial and antiviral activity. In this proof of principle 6 months study, the effects of supplementing a PHT mix, Phyto V7, to HIV-1 seropositive individuals and AIDS patients were examined. Individuals with CD4+ T-cells below 350 counts/mm3were assigned to one of the following treatments: CG1 - no treatment, CG2 - only highly active antiretroviral treatment (HAART), TG1 - only Phyto V7, and TG2- both Phyto V7 and HAART. After 3 months of treatment there were approximately (-)1%, 1%, 2% and 4% increase in the mean weight of the CG1, CG2, TG1 and TG2 groups, respectively. The tendency for the body mass index (BMI) was similar. The CD4+ counts increased by 13%, 39%, 53% and 35%, respectively....

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Induction of Antioxidant Capacity and Hydroxymethylfurfural Content Variations by Modifications of Cooked Fruit Processing.

Abstract:

Liège syrup is a Belgian traditional cooked fruit foodstuff, produced mainly from apples and pears. The process includes several hours of heating at high temperature during which complex chemical reactions occur, such as Maillard condensation between reducing sugars and amino acids. Aiming at understanding the modifications of the fruit juices during heating, different parameters were monitored throughout the process. It was shown that hydoxymethylfurfural was formed during the first step of concentration by heating. At the end of the process, hydroxymethylfurfural had totally disappeared and the deep brown color of the product suggested that this compound was transformed into melanoidins. A parallel increase in antioxidant capacity was also observed. To determine optimal conditions to reach high melanoidin content and high antioxidant capacity, different in vitro model systems were compared. It was shown that different combinations of an amino a...

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Tourette’s Syndrome: Medical, Educational and Behavior Therapy

Abstract:

The French physician, Gill de la Tourette, was the first person to define Tourette’s Syndrome (TS) in 1885 and has brought much attention to it in Western countries for the past few decades. Unfortunately, most Asian countries are not familiar with Tourette’s Syndrome. Tourette’s Syndrome is regarded as a disorder of the nerve system that often appears with involuntary tic behaviors. The purpose of this article is to give a better understanding of Tourette’s Syndrome, starting with a brief background, followed by its pathogenesis and an analysis of treatment, including medication and education. The related studies of Tourette’s syndrome are also discussed in this study.

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Multiple Cerebral, Calcified and Infected Hydatid Cysts Case Report and Literature Review

Abstract:

Calcified and Infected Hydatid Cysts Case Report and Literature Review

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