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Early Stressful Life Events, which Caused Depression Probably are Associated with the Development of Dementia

Abstract:

Recently the results of a large, prospective population study, important for the diagnosis and treatment of dementia were presented 1. The authors emphasize their conclusion already in the title of the paper and state “Stressful life events are not associated with the development of dementia”. They discuss many studies, which lead to an opposing conclusion, namely that there is the causal relationship between stressful, adverse life  events and the risk of dementia, however they  quote also two other papers leading to a denial of such a relationship.

...

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A Successful Vancomycin Treatment of Multidrug-Resistant MRSA-Associated Canine Pyoderma

Abstract:

Case Report

This report describes a case of diffuse pyoderma in a 10-year-old female dog with hypothyroidism. A previous treatment, without an early diagnosis, including cephalosporin associated with prednisolon resulted to be unsuccessfully. After clinical and microbiological examination in our laboratories, a diagnosis of methicillinresistant Staphylococcus aureus (MRSA)-associated pyoderma was made. The antimicrobial susceptibility testing evidenced many resistances and susceptibility of the strain only to vancomycin and linezolid. A new therapy against hypothyroidism and associated with an appropriate antimicrobial (vancomycin) treatment, improved and resolved the infection.

Clinical Significance

To our knowledge, this is the first case of canine pyoderma caused by a strain of MRSA with a such severe multiresi...

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Rare cause of gastric varices secondary to an isolated left gastric vein stenosis

Abstract:

A 69 year old female with a history of pancreatic mucinous cystadenoma (treated with Whipple procedure) and recently presumed liver cirrhosis presented to the hospital with melanotic stools. The source of the bleeding was initially thought to be secondary to upper gastrointestinal (GI) varices due to portal hypertension from the liver disease. Upper endoscopy found no active bleeding and confirmed grade 2 gastric varices with gastric wall edema. Due to persistent symptoms and inability to locate the exact source, she went to the operating room for possible transjugular intrahepatic portosystemic shunt (TIPS) but was not found to have any porto-systemic gradient. Instead, she was found to have an isolated stenosis of the left gastric vein, which was treated with balloon angioplasty and eventual splenectomy. Upper GI varices usually occur due to portal hypertension from liver disease. Extra hepatic causes are much rarer. We report a case of upper GI bleed from gastr...

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Prevalence of Impulse Control Disorders among Adult Filipino Patients with Idiopathic Parkinson’s Disease seen at Jose R. Reyes Memorial Medical Center

Abstract:

Background:

Impulse Control Disorders (ICDs) are characterized as pathologicalbehavioral patterns of excess impulsivity which may result as part of the non-motor complications of Parkinson’s disease (PD). These significantly affect the patient’s overall quality of life and have impact on their care givers, as well. Currently, the prevalence of ICDs among adult Filipino patients with Parkinson’s disease is unknown and less reported.

Objectives:

The study is intended to determine the prevalence of ICDs and its severityamong adult Filipino patients with idiopathic Parkinson’s disease seen at Jose R. Reyes Memorial Medical Center. Specifically, this study will identify risk factors and the clinical correlates to these patients.

 M...</p> <a class="btn btn-primary blue-btn text-uppercase my-4" href="https://openaccesspub.org/neurological-research-and-therapy/article/361">Read Article</a> </div> </div> <div class="col-md-6 mb-3 aos-item aos-init " data-aos="fade-up"> <!-- child-div --> <div class="article-section p-3"> <h4 class="article-title title-border pb-3"> Distinguishing between Knowledge Gaps and Misconceptions of Alzheimer’s Disease among Caregivers in the UK</h4> <h4 class="article-title fw-700">Abstract:</h4> <p><abstract> <p>A popular scale for assessing knowledge about Alzheimer’s disease is the Alzheimer’s Disease Knowledge Scale (ADKS). The aim of the study was to investigate the effect of adding ‘don’t know’ to the original ‘true’ or ‘false’ response option. It was assumed that this modification would provide insight into the reasons underlying incorrect responses and could distinguish between misconceptions and knowledge gaps. To investigate this, carers (care home carers and informal carers) and members of the general population were recruited. The results showed that percentage correct responses was lower than previously reported, suggesting potential inflation of knowledge by guesses without the ‘don’t know’ option. Moreover, care-home workers were more likely to select the incorrect response than ‘don’t know’ compared to informal carers for several items related to the earlier stages of AD, suggesting a higher level of misconceptions around this ...</p> <a class="btn btn-primary blue-btn text-uppercase my-4" href="https://openaccesspub.org/aging-research-and-healthcare/article/362">Read Article</a> </div> </div> <div class="col-md-6 mb-3 aos-item aos-init " data-aos="fade-up"> <!-- child-div --> <div class="article-section p-3"> <h4 class="article-title title-border pb-3"> Childhood Somatic Complaints: Relationships with Child Emotional Functioning and Parental Factors</h4> <h4 class="article-title fw-700">Abstract:</h4> <p><abstract> <p>Many schoolchildren experience somatic complaints such as headaches, abdominal pain and fatigue. The aim of the current research is to test the full model of previously found associations between negative affect and somatic complaints in parents and children. Participants were 199 children (aged 8-13, 47% boys) and their parents (aged 31-61, mostly mothers (87%). Self-reports of children and parents on worry, anxiety, depression and somatic complaints were used and parents’ reactions to children’s emotions wereassessed. The results of the study show that childhood negative affect and parental somatic complaints are positively associated with childhood somatic complaints. In turn, childhood negative affect is related to children’s worrying and to parents’ responses to children’s emotions. The more anxious or depressed children felt, the more they worried. Maladaptive parental responses (such as reprimands and discomfort) to child emotions were positively ...</p> <a class="btn btn-primary blue-btn text-uppercase my-4" href="https://openaccesspub.org/behavior-therapy-and-mental-health/article/359">Read Article</a> </div> </div> <div class="col-md-6 mb-3 aos-item aos-init " data-aos="fade-up"> <!-- child-div --> <div class="article-section p-3"> <h4 class="article-title title-border pb-3"> Spontaneous Carotid-Cavernous Fistula and Subarachnoid Hemorrhage</h4> <h4 class="article-title fw-700">Abstract:</h4> <p><abstract> <p>Carotid-cavernous fistula (CCF) is a rare neurological condition with risk of death in case of inappropriate management. The outcome of this pathology is very bad in developing countries with inadequate technical Platform. We underlined the main difficulties of the management of CCF in a 43 years-old Togolese woman with a fatal outcome.</p> </abstract>...</p> <a class="btn btn-primary blue-btn text-uppercase my-4" href="https://openaccesspub.org/neurological-research-and-therapy/article/356">Read Article</a> </div> </div> <div class="col-md-6 mb-3 aos-item aos-init " data-aos="fade-up"> <!-- child-div --> <div class="article-section p-3"> <h4 class="article-title title-border pb-3"> An Optical Chemical Sensor for Determination of Nickel in Water and Hydrogen Peroxide Samples</h4> <h4 class="article-title fw-700">Abstract:</h4> <p><abstract> <p>Application of nickel in different industries has been developed and so contamination of natural water is a great concern due to its potentially toxic effects on living beings. Therefore, fast monitoring of Ni<sup>2+</sup> in aqueous samples is important. In this work, we fabricated a sensitive optical sensor for determination of nickel in mineral water samples and hydrogen peroxide solutions. The optode was prepared by incorporation of 1-(2-pyridylazo)-2-naphthol and sodium tetraphenylborate in a plasticized poly (vinyl chloride) membranes containing dioctyladipate as a plasticizer. The influence of several parameters such as pH, base matrix, solvent mediator and ligand concentration were optimized. Comparison the obtained results with previously reported sensors revealed that the proposed method, in addition to fast and simplicity, provided good linear range (1.70–85.20 µmol L<sup>-1</sup>) and low detection limit (0.17 µmol L<sup>-1</sup>). The precision (r...</p> <a class="btn btn-primary blue-btn text-uppercase my-4" href="https://openaccesspub.org/new-developments-in-chemistry/article/357">Read Article</a> </div> </div> <div class="col-md-6 mb-3 aos-item aos-init " data-aos="fade-up"> <!-- child-div --> <div class="article-section p-3"> <h4 class="article-title title-border pb-3"> Synthesis and Assessment of a New Tetrahydrogeraniol Derivative as Penetration Enhancer for Transdermal Drug Delivery </h4> <h4 class="article-title fw-700">Abstract:</h4> <p><abstract> <sec id="idm1851375636"> <title>Background:

Skin is one the most important sites for administration of drugs to obtain desired pharmacological effects either locally or through systemic bioavailability; and this has placed the transdermal route of drug delivery as an attractive and as one of the most innovative areas for conducting drug delivery research. However the stratum corneum in skin creates hurdles and acts as significant barrier for the permeation of drugs through skin. Penetration enhancers play a pivotal role to overcome such barriers and help enhance the permeation of drug through skin. However, penetration enhancement technology is challenging development and needs to be properly and skillfully addressed.

Objective:

The present investigation aimed to study the penetration enhancing effect of a newly...

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The Use of Predictive Markers for the Development of a Model to Predict Lowest Quartile Weight Loss following Roux-en-Y Gastric Bypass.

Abstract:

Introduction:

The Roux-en-Y Gastric Bypass (RYGB) has been one of the most popular surgeries in the USA for years. While many models have been made to investigate the factors that affect weight loss, these factors are still highly debated.

Objective:

To create a model that predict performance of RYGB patients.

Methods:

110 out of 344 patients who received a RYGB at a single institution between Jan 2010 and April 2014 were included in this study. Data was collected retrospectively. Patients were included if they had greater than 1 year follow up with at least three follow up points and could be modeled with r2>0.95. All patients were one year beyond surgery, while 40 were completely lost to follow up, 104 at 1 ...

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