Research Topic · Peer-Reviewed

Extracellular Matrix

The extracellular matrix (ECM) is the complex network of proteins and polysaccharides secreted by cells that provides structural and biochemical support to surrounding tissues. Its components, including collagens, elastin, fibronectin, laminins, proteoglycans, and glycosaminoglycans, form scaffolds that determine ti…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 352× across the literature 🔖 ISSN 2640-6403 🗓 Reviewed July 2026

Overview

The extracellular matrix (ECM) is the complex network of proteins and polysaccharides secreted by cells that provides structural and biochemical support to surrounding tissues. Its components, including collagens, elastin, fibronectin, laminins, proteoglycans, and glycosaminoglycans, form scaffolds that determine tissue architecture and mechanical properties while regulating cell adhesion, migration, proliferation, differentiation, and signalling. The ECM is dynamically remodelled by enzymes such as matrix metalloproteinases, and its composition and turnover are central to tissue growth, wound healing, fibrosis, and regeneration, making it a key focus of tissue engineering and the design of biomaterial scaffolds. Research in this area examines wound-healing models, including a diabetic delayed-wound model and the differential influence of acute and chronic wound fluid in a three-dimensional in-vitro wound model, the degradation of chitosan scaffolds by lysozyme, and calcium-orthophosphate scaffolds for bone tissue engineering. Adjacent work addresses microRNA-based activation of dental implant surfaces, the mechanical elasticity of skin, neuronal, cardiac, and skeletal muscle cells, epithelial–mesenchymal transition in tumour biology, and the regulation of matrix metalloproteinase by glucose and insulin. Studies draw on cell-based assays, biomaterial characterisation, and tissue-engineering approaches. The journal publishes peer-reviewed research on the extracellular matrix, scaffolds, and Tissue Repair and Regeneration.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2018

The Use of Mirnas as Activators of Dental Implant Surfaces, A Review

Di Gianfilippo RiccardoCorresponding author
The University of Michigan - School of Dentistry, Department of Periodontics and Oral Medicine, 1011 North University Avenue, 48109-1078, Ann Arbor, MI – USA
Exact topic International Journal of Bone and Mineral Metabolism

How this research is being cited

The 12 articles above have been cited 352 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Extracellular Matrix, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Tissue Repair and Regeneration (ISSN 2640-6403).

Journal editorial board
Walid Rachidi · France Ilaria Baldelli · Italy Costica Aloman · United States

This page summarises published research for orientation; it is not medical or professional advice.