Hypothyroidism is a clinical state of deficient thyroid hormone action, most often resulting from inadequate production of thyroxine (T4) and triiodothyronine (T3) by the thyroid gland. Primary hypothyroidism, the commonest form, arises from gland failure—frequently autoimmune (Hashimoto's) thyroiditis, iodine defic…
Hypothyroidism is a clinical state of deficient thyroid hormone action, most often resulting from inadequate production of thyroxine (T4) and triiodothyronine (T3) by the thyroid gland. Primary hypothyroidism, the commonest form, arises from gland failure—frequently autoimmune (Hashimoto's) thyroiditis, iodine deficiency or excess, or iatrogenic causes such as thyroidectomy, radioiodine, and certain drugs—whereas central hypothyroidism reflects pituitary or hypothalamic dysfunction. Biochemically it is defined by elevated TSH with low free T4 in primary disease, and treated with levothyroxine titrated to symptoms and thyrotropin targets. Because thyroid hormones regulate basal metabolic rate, thermogenesis, cardiac output, and the development of multiple organ systems, deficiency produces fatigue, weight gain, cold intolerance, bradycardia, constipation, and, when severe or untreated, myxedema. Thyroid dysfunction interacts closely with other systems: it is prevalent in chronic kidney disease, influences adipose physiology and obesity, and affects reproductive and testicular structure, with experimental models examining protective interventions. Iodine status, including exposure to iodinated radiographic contrast agents, can perturb thyroid function and precipitate dysfunction in susceptible patients. Research in this area spans endocrine, renal, metabolic, and developmental contexts. The journal publishes peer-reviewed clinical and experimental studies on thyroid hormone deficiency, its systemic consequences, and its management.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 65 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Hypothyroidism, linking to each citing work.