Research Topic · Peer-Reviewed

Spinal Cord Injury

Spinal cord injury is damage to the spinal cord that disrupts the transmission of motor, sensory, and autonomic signals between the brain and the body below the level of the lesion. It is classified by anatomical level and by completeness, with complete injuries abolishing function below the lesion and incomplete in…

Curated from this journal's research 📚 9 peer-reviewed articles cited Cited 40× across the literature 🔖 ISSN 2694-2283 🗓 Reviewed July 2026

Overview

Spinal cord injury is damage to the spinal cord that disrupts the transmission of motor, sensory, and autonomic signals between the brain and the body below the level of the lesion. It is classified by anatomical level and by completeness, with complete injuries abolishing function below the lesion and incomplete injuries sparing variable motor or sensory capacity. Injuries arise from traumatic mechanisms, including falls, vehicle collisions, and sport, where equestrian and other high-impact activities carry notable risk, as well as from vascular and structural causes such as arteriovenous fistulae and other lesions affecting cord perfusion. The pathophysiology involves primary mechanical disruption followed by a secondary cascade of ischemia, oxidative stress, inflammation, and cell death that extends tissue damage over time; experimental work on oxidative injury in neural cells and on the molecular biology of oligodendrocytes, myelination, and signaling pathways such as Wnt informs understanding of this progression. Consequences range from paralysis and altered sensation to disturbances of bladder, bowel, and cardiovascular control. Research directions include neuroprotection to limit secondary injury, and regenerative strategies using stem cells, biocompatible scaffolds, and three-dimensional neural culture to support repair and remodeling. Clinically, management combines acute stabilization, prevention of complications, and long-term rehabilitation aimed at maximizing function, independence, and quality of life.

Research published in this journal

9 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 9 articles above have been cited 40 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Spinal Cord Injury, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Sports and Exercise Medicine (ISSN 2694-2283).

Journal editorial board
Gerasimos Grivas · Greece Angelo Cataldo · Italy Guy CHERON · Belgium

This page summarises published research for orientation; it is not medical or professional advice.