Disorders of the liver encompass the diseases and dysfunctions affecting hepatic structure and function, with consequences for the organ's central roles in detoxification, metabolism, protein and bile synthesis, and storage. Because the liver supports many systemic processes, its disorders can affect coagulation, nu…
Disorders of the liver encompass the diseases and dysfunctions affecting hepatic structure and function, with consequences for the organ's central roles in detoxification, metabolism, protein and bile synthesis, and storage. Because the liver supports many systemic processes, its disorders can affect coagulation, nutrition, immunity, and the function of other organs. Causes are diverse and include viral and other infections, autoimmune disease, genetic and metabolic conditions, toxic and drug-induced injury, alcohol, and vascular or neoplastic processes, which together produce a spectrum from acute injury to chronic disease, fibrosis, cirrhosis, and hepatocellular carcinoma. Research relevant to this topic includes hospital-based studies of the magnitude and trends of chronic liver disease, the relationship between plasma biomarkers, alcohol use, and liver enzymes in alcohol-use disorder, and experimental work on protection against chemically induced hepato- and nephrotoxicity. Studies of inherited bleeding disorders arising from coagulation-factor mutations underscore the liver's role in haemostasis, while biomarker-based assessments of vital-organ health reflect efforts to detect hepatic injury. Sub-areas include viral and autoimmune hepatitis, fatty and alcoholic liver disease, drug-induced liver injury, cirrhosis and portal hypertension, hepatic malignancy, and inherited metabolic liver disorders. Understanding disorders of the liver is fundamental to hepatology, guiding diagnosis, biomarker development, and the prevention and treatment of hepatic and systemic complications.
10 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 10 articles above have been cited 15 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Disorders of the Liver, linking to each citing work.