Mechanical ventilation is the artificial support or replacement of spontaneous breathing using a device that moves gas into and out of the lungs to maintain adequate oxygenation and carbon dioxide elimination. It is delivered invasively through an endotracheal tube or tracheostomy, or non-invasively via face or nasa…
Mechanical ventilation is the artificial support or replacement of spontaneous breathing using a device that moves gas into and out of the lungs to maintain adequate oxygenation and carbon dioxide elimination. It is delivered invasively through an endotracheal tube or tracheostomy, or non-invasively via face or nasal mask, and is indicated in respiratory failure, severe pneumonia, acute respiratory distress syndrome, and perioperative and critical-care settings. Ventilators are configured by mode, pressure or volume targets, positive end-expiratory pressure, and inspired oxygen fraction, with the goal of supporting gas exchange while minimizing ventilator-induced lung injury and optimizing patient-machine synchrony. Complications include barotrauma, ventilator-associated pneumonia, and diaphragmatic dysfunction, and weaning and alternatives such as diaphragmatic pacing are important clinical considerations. Adequacy of gas exchange during support is assessed through arterial blood gases and measures such as the alveolar-arterial oxygen difference. Research relevant to this area examines diaphragmatic pacing as an alternative to mechanical ventilation, devices to improve patient-machine synchronization in non-invasive ventilation, the diagnosis of acute respiratory distress syndrome using alveolar-arterial gradients in pneumonia, rehabilitation of sepsis patients in intensive care, and respiratory management during viral pneumonia. This peer-reviewed literature reflects the indications, technical principles, complications, and weaning of ventilatory support relevant to airway and respiratory disease within the broader study of respiratory and sinonasal medicine.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 6 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Mechanical Ventilation, linking to each citing work.