Systemic Inflammatory Response Syndrome (SIRS) is a widespread inflammatory reaction of the body to a serious insult such as infection, trauma, burns, surgery, or other major illness. It is defined clinically by a combination of measurable changes, including abnormal body temperature, elevated heart rate, rapid brea…
Systemic Inflammatory Response Syndrome (SIRS) is a widespread inflammatory reaction of the body to a serious insult such as infection, trauma, burns, surgery, or other major illness. It is defined clinically by a combination of measurable changes, including abnormal body temperature, elevated heart rate, rapid breathing, and an abnormal white blood cell count. SIRS reflects an exaggerated activation of the immune system that, while initially protective, can become harmful when it spreads beyond the original site of injury. When SIRS arises from infection it is closely related to sepsis, and if uncontrolled it can progress to organ dysfunction and life-threatening multiple organ failure. Recognition and early management are therefore important in critical care. Within the journal's coverage of respiratory and inflammation-related disease, related research includes experimental studies evaluating inflammatory serum cytokines and antioxidant and anti-inflammatory effects in animal models of SIRS induced by cecal slurry, lipopolysaccharide, and E. coli. This page gathers peer-reviewed, open-access research relevant to systemic inflammatory response syndrome, the body's inflammatory response to severe illness, and its relationship to sepsis and organ injury.
5 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 5 articles above have been cited 8 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Systemic Inflammatory Response Syndrome, linking to each citing work.