Research Topic · Peer-Reviewed

Biomarker Discovery

Biomarker discovery is the systematic process of identifying and validating measurable biological indicators, molecules or characteristics that signal a normal or pathological state, or a response to treatment. Biomarkers may be proteins, nucleic acids such as microRNAs, metabolites, or genetic and cellular features…

Curated from this journal's research 📚 9 peer-reviewed articles cited Cited 20× across the literature 🔖 ISSN 2326-0793 🗓 Reviewed July 2026

Overview

Biomarker discovery is the systematic process of identifying and validating measurable biological indicators, molecules or characteristics that signal a normal or pathological state, or a response to treatment. Biomarkers may be proteins, nucleic acids such as microRNAs, metabolites, or genetic and cellular features, and they are used to detect disease early, classify and stage it, predict risk and prognosis, and guide and monitor therapy. Discovery typically proceeds from high-throughput screening of biological samples through candidate identification, analytical and clinical validation, and assessment of utility, drawing on proteomics, genomics, and increasingly on advanced experimental and computational platforms. Research in this area surveys proteomic and genomic techniques in medical research and their application to cancer, diagnostics, and personalized medicine, and describes high-throughput disease-modelling platforms for cancer biomarker development. Studies that use a reproducible, ion-current-based proteomics strategy to map the response to lapatinib treatment illustrate the discovery of protein markers, while work employing microfluidic assays and digital PCR to quantify microRNAs for the diagnostic screening of colon cancer demonstrates nucleic-acid biomarker development for low-resource settings. Analysis of dynamic plasma microRNA expression in melanoma in relation to progression, PD-L1 status, and survival links candidate markers to clinical outcome. Together these threads span the proteomic and genomic identification, validation, and clinical application of biomarkers, underpinning early diagnosis, prognosis, and the personalization of treatment.

Research published in this journal

9 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2018

Molecular Biomarkers: A Brief Review

Tarassishin LeonidCorresponding author
 Department of Biological Sciences.
Proteomics and Genomics Research doi:10.14302/issn.2326-0793.jpgr-18-2418

How this research is being cited

The 9 articles above have been cited 20 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Biomarker Discovery, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Proteomics and Genomics Research (ISSN 2326-0793).

Journal editorial board
Sutopa Dwivedi · United States Liuyang Wang · United States Juan Sainz · Spain

This page summarises published research for orientation; it is not medical or professional advice.