Autoimmune disease arises when the immune system loses tolerance to self and mounts a sustained adaptive response against the body's own antigens, mediated by autoreactive T lymphocytes, autoantibodies, or both, with resulting chronic inflammation and tissue injury. Loss of tolerance reflects the interplay of geneti…
Autoimmune disease arises when the immune system loses tolerance to self and mounts a sustained adaptive response against the body's own antigens, mediated by autoreactive T lymphocytes, autoantibodies, or both, with resulting chronic inflammation and tissue injury. Loss of tolerance reflects the interplay of genetic susceptibility, including HLA and other immune-regulatory loci, with environmental triggers such as infections, vaccines, drugs, and microbiome alterations that may act through molecular mimicry, bystander activation, or epitope spreading. Disorders may be organ-specific, as in type 1 diabetes, autoimmune thyroid disease, or multiple sclerosis, or systemic, as in lupus and rheumatoid arthritis, and several can cluster, exemplified by autoimmune polyglandular syndromes. Diagnosis relies on clinical patterns, autoantibody and laboratory testing, and imaging, while management centers on immunomodulation and immunosuppression, control of inflammation, and treatment of complications. Phototherapy and other immune-targeted approaches are studied in selected conditions, and epigenetic and nutritional influences are increasingly recognized in disease modulation. The peer-reviewed research compiled here engages these themes, including the genetic, inflammatory, and environmental basis of autoimmune disease, immune thrombocytopenia diagnostics and treatment, multiple sclerosis and its phototherapy and neurological associations, a possible autoimmune polyglandular syndrome, post-vaccination macrophage-mediated liver injury, and epigenetic and dietary contributions to immune-mediated disease.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 15 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Autoimmune Disease, linking to each citing work.