Alzheimer disease is a progressive neurodegenerative disorder and the most common cause of dementia, characterized clinically by insidious decline in episodic memory, language, executive function, and ultimately independence in daily living. Its defining neuropathology comprises extracellular amyloid-beta plaques an…
Alzheimer disease is a progressive neurodegenerative disorder and the most common cause of dementia, characterized clinically by insidious decline in episodic memory, language, executive function, and ultimately independence in daily living. Its defining neuropathology comprises extracellular amyloid-beta plaques and intraneuronal neurofibrillary tangles of hyperphosphorylated tau, accompanied by synaptic loss, neuroinflammation, and regional atrophy that is often most pronounced in the medial temporal lobe and hippocampus. Disease expression reflects the interplay of age, genetic susceptibility, vascular and metabolic risk factors, and emerging molecular contributors such as microglial signaling and non-coding regulatory RNAs. Diagnosis integrates cognitive assessment, structural and functional neuroimaging, and biomarkers, with growing interest in retinal optical coherence tomography and blood-based markers for earlier detection. Because no treatment reverses the underlying degeneration, care emphasizes timely diagnosis, management of comorbid depression and sleep disturbance, caregiver education, and non-pharmacological and assistive-technology interventions that support adaptive skills and quality of life. The peer-reviewed research assembled here addresses several of these dimensions, including assistive-technology and cognitive-behavioral programs, non-pharmacological management of disrupted sleep in moderate-to-severe dementia, the relationship between cortisol, depression, and medial temporal lobe atrophy, retinal imaging for early prediction, and caregiver knowledge gaps, alongside molecular and bioinformatic perspectives on the disease.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 34 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Alzheimer Disease, linking to each citing work.