Overview
Bark is the outermost tissue of woody stems, branches, and roots, comprising all tissues external to the vascular cambium, including the secondary phloem, the cork cambium, and the protective cork or periderm. It performs essential protective and physiological roles, shielding the plant against water loss, mechanical injury, pathogens, and temperature extremes, while the inner bark conducts photosynthate. Bark is also a rich source of secondary metabolites, including saponins, tannins, alkaloids, and other phytochemicals, which underlies its long-standing use in traditional medicine and its interest as a reservoir of bioactive natural products for pharmacological investigation and standardisation. Research in this area examines the morpho-anatomical and physicochemical standardisation of stem bark, acute and subacute toxicity of stem-bark aqueous extracts in rodents, dose–response characterisation of saponins isolated from stem bark, and the effects of stem-bark extracts on lipid profile and hepatic histology. Further work addresses analgesic and antipyretic activity of root bark, antimicrobial activity of leaf, stem-bark, and root extracts, and the broader phytochemistry of medicinal plant materials. Studies draw on pharmacognostic standardisation, extract preparation, and in vivo and in vitro bioassays of plant-derived compounds. The journal publishes peer-reviewed research on plant tissues and their bioactive constituents.
Research published in this journal
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
Acute and Subacute Toxicity Evaluation of the Stem Bark Aqueous Extract of Harungana Madagascariensis in Rodents
Dose Response of Total Saponins Isolated from the Stem Bark of Dialium Guineense
Effect of Extracts of Dialium guineense Stem Bark on Lipid Profile and CCl4- Induced Histological Changes in Liver of Wistar Rats
Analgesic and Anti-Pyretic Activities of the Root Bark of Rutidea Parviflora (Rubiaceae)
Investigation of Antimicrobial Activity of the Extracts of the Leaves, Stembark and Root of Allanblackia floribunda: An Alternative Paradigm Shift Outcome.
Complementary and Alternative Treatments for Cancer Prevention and Cure (Part 1)
Phytochemicals May Arrest HIV-1 Progression
Structure Activity Relationship of Xanthones for Inhibition of Cyclin Dependent Kinase 4 from Mangosteen (Garcinia Mangostana L.)
Biolarvicidal Potentials of the Methanolic-Leaf-Extracts of Selected Tropical Plant Species
Colored Anti-Hail Nets Modify the Ripening Parameters of Nebbiolo and a Smart NIRS can Predict the Polyphenol Features
Evaluation of Cinnamon Supplementation on Insulin Resistance, BMI and Estradiol Levels in Women with Polycystic Ovary Syndrome: A Double-Blinded Randomized Controlled Clinical Trial
How this research is being cited
The 12 articles above have been cited 108 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
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2026 · Molecular Nutrition & Food Research
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2026 · Malacca Pharmaceutics
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2026 · Nutrients
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2026 · Natural Product Research
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2026 · Plant Physiology and Biochemistry
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Goddidit Esiro Enoyoze et al. · 2025 · Toxicology International
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2025 · Current Drug Research Reviews
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2025 · Toxicology International
A sample of recent works citing this journal's research on Bark, linking to each citing work.