Research Topic · Peer-Reviewed

Palmitoyl Pentapeptide-4

Palmitoyl Pentapeptide-4 is a small chain of five amino acids linked together with a fatty acid (palmitic acid) at one end. It is a signal molecule that sends a message to the skin to increase collagen and elastin production, resulting in an improvement in skin elasticity and firmness. This peptide also stimulates t…

📚 0 peer-reviewed articles cited 🗓 Reviewed July 2026

Overview

Palmitoyl Pentapeptide-4 is a small chain of five amino acids linked together with a fatty acid (palmitic acid) at one end. It is a signal molecule that sends a message to the skin to increase collagen and elastin production, resulting in an improvement in skin elasticity and firmness. This peptide also stimulates the production of hyaluronic acid in the skin for greater hydration, and can help to reduce the appearance of wrinkles, fine lines and age spots. Palmitoyl Pentapeptide-4 can be used in both topical and oral forms for improved skin health and appearance, and has been increasingly studied and used for skin care purposes in recent years.

Research published in this journal

No peer-reviewed research on this exact topic has been published in Peptides yet. Browse the journal →

Editorial oversight

Curated from peer-reviewed research published in Peptides.

Journal editorial board
Laura Zaccaro · Italy Emilia Pedone · Italy Dulari Jayawardena · United States

This page summarises published research for orientation; it is not medical or professional advice.