Research Topic · Peer-Reviewed

Dipeptide

A dipeptide is a molecule composed of two amino acids joined by a single peptide bond, representing the simplest form of peptide structure. Research published in Peptides addresses fundamental challenges in dipeptide and peptide synthesis, particularly focusing on aqueous-phase solid-phase peptide synthesis methods …

Curated from this journal's research 📚 3 peer-reviewed articles cited Cited 21× across the literature 🗓 Reviewed July 2026

Overview

A dipeptide is a molecule composed of two amino acids joined by a single peptide bond, representing the simplest form of peptide structure. Research published in Peptides addresses fundamental challenges in dipeptide and peptide synthesis, particularly focusing on aqueous-phase solid-phase peptide synthesis methods that offer alternatives to traditional organic solvent approaches. Studies have examined protective strategies for amino acid side chains during synthesis, including the use of host-affinity molecules to protect lysine residues, as well as the development of reusable solid-phase systems for peptide assembly in water-based environments. Beyond synthetic methodology, the journal has explored the biological significance of specific dipeptides and related small Peptides in physiological processes, including investigations into N-acetylaspartylglutamate, a dipeptide derivative implicated in neurovascular coupling and the regulation of cerebral blood flow through astrocyte-mediated mechanisms. This research contributes to understanding both the technical aspects of constructing dipeptide molecules efficiently and sustainably, and their roles as signaling agents in complex biological systems, bridging synthetic chemistry with neuroscience and vascular physiology.

Research published in this journal

3 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 3 articles above have been cited 21 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Dipeptide, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Peptides.

Journal editorial board
Laura Zaccaro · Italy Emilia Pedone · Italy Dulari Jayawardena · United States

This page summarises published research for orientation; it is not medical or professional advice.