Journal of

International Journal of Global Health

Current Issue Volume No: 1 Issue No: 1

ISSN: 2693-1176
share this page

Editorial Article Open Access
  • Available online freely Peer Reviewed
  • Global Health Involvement in Thyroid Cancer Incidence Increase

    Lucio Mango 1  

    1Head of Higher Education in Healthcare, International University of Rome (UNINT) Italy, Via San Godenzo, 154 00189 Rome, Italy.


    In recent decades was observed a gradual increase in the detection of thyroid nodules in the adult population. Given the increase in prevalence of nodules, a similar trend to the growth in the incidence of thyroid cancers was found. The reasons for this increased incidence for thyroid cancer are controversial. Increased incidence is caused by an improvement in diagnostic techniques or does not result from an overdiagnosis, but represents a real increase in the incidence of thyroid cancer? Whatever the reality, the fact of an increased incidence of thyroid cancer for certain involves problems to global health which in any case must be evaluated and corrected.


    Author Contributions
    Received 02 May 2020; Accepted 14 May 2020; Published 15 May 2020;

    Academic Editor: Nasim Habibzadeh, School of Health and Life Since, Teesside University, United Kingdom.

    Checked for plagiarism: Yes

    Review by: Single-blind

    Copyright ©  2020 Lucio Mango

    Creative Commons License     This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

    Competing interests

    The authors have declared that no competing interests exist.


    Lucio Mango (2020) Global Health Involvement in Thyroid Cancer Incidence Increase . International Journal of Global Health - 1(1):14-17.

    Download as RIS, BibTeX, Text (Include abstract )

    DOI 10.14302/issn.2693-1176.ijgh-20-3353


    In recent decades, the epidemiology of nodular thyroid disease has changed, with a gradual increase in the detection of thyroid nodules in the adult population 1.

    In Italy, for example, the prevalence of thyroid nodules in this population is 50% with peaks of up to 75% in some regions 2. Given the increase in prevalence of nodules, a similar trend to the growth in the incidence of thyroid cancers was found 3.

    The observed increase is more pronounced in women (8.1%/year) than men (6.2%/year) 4. This trend is also observed in other countries despite the geographical variability of the phenomenon with an average global increase of 58.1% with the exception of Sweden where there is an 18% decrease for both sexes 5, 6, 7.

    Compared to the various histological forms in which thyroid carcinoma occurs, the truly significant increase concerns papillary carcinoma 8, an increase that affects all racial groups and the two sexes. Regarding the rate of increase in papillary carcinoma, the increase in the incidence of the disease tends to be faster among females than males. However, it was seen that rates have also increased for larger tumors and more advanced stage. Some Authors claim that although the largest increases were observed between early and smaller cancers, they did not observe reduction in larger and more advanced tumors; they found that cancers of all sizes have increased over time 9.

    However, with increasing incidence of thyroid cancer, mortality from this disease has remained stable at about 0.5 deaths per 100,000 population 3. Anyhow, if compared to the mortality of other carcinomas, which is decreased, there is a slight increase for thyroid tumors.


    The reasons for this increased incidence for thyroid cancer are controversial.

    Many experts say that the increased incidence is caused by an improvement in diagnostic techniques 10, 11, first of all the ultrasound with high frequency probes and the diffusion of the cytological examination of the fine needle aspiration(FNA). This therefore configures an overdiagnosis which would lead to overtreatment with possible negative consequences. For example, in terms of costs that would increase, but also of the risks resulting from invasive treatments such as surgery.

    However, there is the possibility that the increase does not result from an overdiagnosis, but represents a real increase in the incidence of thyroid cancer. In favor of this hypothesis contributes the mentioned detection of increase of not only small tumors and in an early stage of development, but also medium or large and in a more advanced stage. Also the finding of an increase almost only for papillary carcinomas contributes to the hypothesis that in any case the increased incidence also derives from real reasons. The increase of some specific papillary carcinoma carcinogens might explain the above phenomenon, think eg. the increase of the presence of BRAF-positive papillary carcinomas 12, 13.

    Even if a different screening intensity depending on the age and sex can not be excluded, the different trend observed in the two sexes and the age coincidences suggest that the detection gain is not the only cause of the increased incidence of thyroid cancer. Race-specific trends also do not support a detection effect as reason for the increasing incidence 14.

    One of the causes of real increase may be due to the increase in radiation, especially those arising from medical diagnostics. The effect of radiation as a cause of cancer is known and the thyroid gland is very exposed for its position in the human body. Moreover, as demonstrated by the increase in thyroid cancers, especially in children after the Chernobyl disaster for131 iodine fallout 15 the thyroid gland of young people is very radiosensitive.

    It has also been found that high TSH values can influence the onset of thyroid cancer 16.

    And yet autoimmune thyroiditis could influence cancer risk, not only by increasing TSH levels but also by the autoimmune process itself, through the production of proinflammatory cytokines and oxidative stress 17.

    Furthermore, there is a striking correlation between thyroid cancer, obesity and insulin resistance. These associations can be explained by various proposed pathophysiological mechanisms. So the increase in the prevalence of thyroid cancer is not only due to better detection, but from the known increase in the prevalence of obesity worldwide, which is associated with insulin resistance 18.


    Thyroid nodules are extremely common and can be detected by accurate and sensitive imaging in more than 60% of the general population. They are often identified in symptom-free patients who are evaluated for other diagnostic problems.

    The indiscriminate evaluation of thyroid nodules with thyroid biopsy may cause harmful epidemic of thyroid cancer diagnosis, but an inadequate selection of thyroid nodules for biopsy can lead to failed diagnosis of clinically relevant thyroid carcinoma 19.

    So even if there is a documented increase in incidence due to a better more performing diagnostic process, it also appears true that there is a real increase due to some of the factors mentioned above.

    In any case, whatever the reality, the fact of an increased incidence of thyroid cancer for certain involves problems to global health which in any case must be evaluated and corrected. In fact, if the increase is due to hyper diagnosis, certainly the phenomenon must be alleviated, and mostly concerns the richest and most developed countries.

    But the presence of a real increase leads instead to serious problems in the less developed or developing countries that certainly have less advanced health systems 20 with less diagnostic and therapeutic possibilities. Thus occurring underdiagnosis and undertreatment, with serious social consequences.


    1.Maniakas A, Davies L, Zafereo M E. (2018) Thyroid disease around the world. , Otolaryngol Clin N Am 51, 631-642.
    2.Durante C, Cava F, Paciaroni A, Filetti S. (2008) Benign thyroid nodules: diagnostic and therapeutic approach. Recenti Prog Med. 99(5), 263-70.
    3.Davies L, Welch H G. (2006) Increasing incidence of thyroid cancer in the United States,1973-2002.JAMA10;. 295(18), 2164-7.
    4.Leenhardt L, Grosclaude P, Chérié-Challine L. (2004) Thyroid Cancer Committee2004Increased incidence of thyroid carcinoma in france: a true epidemic or thyroid nodule management effects? Report from the French Thyroid Cancer Committee. , Thyroid 14(12), 1056-60.
    5.Kilfoy B A, Zheng T, Holford T R, Han X, Ward M H. (2008) International patterns and trends in thyroid cancer incidence, 1973-2002. Cancer Causes Control. 20(5), 525-31.
    6.Pandeya N, McLeod D S, Balasubramaniam K, Baade P D, Youl P H. (2016) Increasing thyroid cancer incidence in Queensland, Australia 1982–2008–true increase or overdiagnosis?. , Clinical endocrinology 84(2), 257-264.
    7.Colonna M, Uhry Z, Guizard A V, Delafosse P, Schvartz C. (2015) Recent trends in incidence, geographical distribution, and survival of papillary thyroid cancer in France. , Cancer epidemiology 39(4), 511-18.
    8.Wiltshire J J, Drake T M, Uttley L, Balasubramanian S P. (2016) Systematic review of trends in the incidence rates of thyroid cancer. , Thyroid 26(11), 1541-52.
    9.Enewold L, Zhu K, Ron E, Marrogi A J, Stojadinovic A. (2009) Rising thyroid cancer incidence in the United States by demographic and tumor characteristics, 1980-2005. Cancer Epidemiology and Prevention Biomarkers. 18(3), 784-91.
    10.Grodski S, Brown T, Sidhu S, Gill A, Robinson B. (2008) Increasing incidence of thyroid cancer is due to increased pathologic detection. , Surgery 144(6), 1038-43.
    11.Pellegriti G, Frasca F, Regalbuto C, Squatrito S, Vigneri R. (2013) Worldwide increasing incidence of thyroid cancer: update on epidemiology and risk factors.doi;/10.1155/2013/965212Journal of cancer epidemiology.
    12.Mathur A, Moses W, Rahbari R, Khanafshar E, Duh Q Y. (2011) Higher rate of BRAF mutation in papillary thyroid cancer over time: a single‐institution study. , Cancer 117(19), 4390-95.
    13.Romei C, Fugazzola L, Puxeddu E, Frasca F, Viola D. (2012) Modifications in the papillary thyroid cancer gene profile over the last 15 years. , The Journal of Clinical Endocrinology & Metabolism 97(9), 1758-65.
    14.Zhu C, Zheng T, Kilfoy B A, Han X, Ma S. (2009) A birth cohort analysis of the incidence of papillary thyroid cancer in the United States,1973-2004. Thyroid19(10):. 1061-66.
    15.Bogdanova T I, Saenko V A, Zurnadzhy L Y, Rogounovitch T I, Ito M. (2019) Pathology of radiation-induced thyroid cancer: lessons from Chernobyl thyroid cancer study. In Thyroid FNA Cytology , Singapore 549-63.
    16.Su A, Zhao W, Wu W, Wei T, Ruan M. (2020) The association of preoperative thyroid-stimulating hormone level and the risk of differentiated thyroid cancer in patients with thyroid nodules: A systematic review and , American Journal of Surgery
    17.N Silva de Morais, Stuart J, Guan H, Wang Z. (2019) The impact of Hashimoto thyroiditis on thyroid nodule cytology and risk of thyroid cancer. , Journal of the Endocrine Society 3(4), 791-800.
    18.Harikrishna A, Ishak A, Ellinides A, Saad R, Christodoulou H. (2019) The impact of obesity and insulin resistance on thyroid cancer: a systematic review. Maturitas.
    19.Ospina N S, Iñiguez-Ariza N M, Castro M R. (2020) Thyroid nodules: diagnostic evaluation based on thyroid cancer risk 368:. 6670.
    20.Mango L. (2020) Health systems of underdeveloped and developing countries. in press , International Journal of Global Health (IJGH)