Research Topic · Peer-Reviewed

Liver Transplantation

Liver transplantation is the surgical replacement of a diseased or failing liver with a healthy graft, either a whole organ from a deceased donor or a partial graft from a deceased or living donor. It is the definitive treatment for irreversible, life-threatening liver disease. Principal indications include end-stag…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 77× across the literature 🔖 ISSN 2576-9359

Overview

Liver transplantation is the surgical replacement of a diseased or failing liver with a healthy graft, either a whole organ from a deceased donor or a partial graft from a deceased or living donor. It is the definitive treatment for irreversible, life-threatening liver disease. Principal indications include end-stage cirrhosis from chronic liver disease, acute (fulminant) liver failure, and selected cases of hepatocellular carcinoma confined within accepted criteria, as well as certain metabolic and cholestatic disorders. The standard operation is orthotopic transplantation, in which the recipient's liver is removed and the graft implanted in the same anatomical position. Restoring function requires meticulous vascular anastomoses of the hepatic artery, portal vein, and inferior vena cava, together with biliary reconstruction to re-establish bile drainage. As with other solid-organ grafts, success depends on lifelong immunosuppression to prevent rejection, balanced against risks of infection and drug toxicity. Liver transplantation sits within the broader field of organ transplantation, which also encompasses kidney, heart, and lung grafting and shares core challenges: the immunology of allograft rejection, the personalization and optimization of immunosuppressive regimens, organ allocation, and the ethical dimensions of deceased and living donation. Advances in these shared areas, alongside refinements in surgical technique and perioperative care, continue to shape outcomes across transplantation.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 12 articles above have been cited 77 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Nov 2026.

A sample of recent works citing this journal's research on Liver Transplantation, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Journal of Organ Transplantation (ISSN 2576-9359).

Journal editorial board
Karolina Golab · United States Francesca Diomede · Italy Luca Peruzzotti-Jametti · United Kingdom

This page summarises published research for orientation; it is not medical or professional advice.