Guanine is one of the four nucleobases found in DNA and RNA, where it pairs with cytosine through hydrogen bonding and plays a fundamental role in genetic information storage and transfer. Research published in New Developments in Chemistry has examined guanine primarily through the lens of oxidative damage and its …
Guanine is one of the four nucleobases found in DNA and RNA, where it pairs with cytosine through hydrogen bonding and plays a fundamental role in genetic information storage and transfer. Research published in New Developments in Chemistry has examined guanine primarily through the lens of oxidative damage and its biomedical implications. One focus area involves the oxidized derivative 8-oxo-7,8-dihydro-2'-deoxyguanosine, a biomarker of oxidative stress that forms when guanine residues in DNA are damaged by reactive oxygen species. Published work has compared analytical methods for detecting this oxidative marker in human urine, evaluating high-performance liquid chromatography coupled with tandem mass spectrometry against commercial immunoassay techniques to improve measurement accuracy. The journal has also addressed guanine-related processes in the context of colorectal pathology, exploring molecular pathways in carcinogenesis where DNA damage and repair mechanisms are central. Additionally, metabolomic approaches have been discussed as tools for assessing environmental exposures that may affect guanine and other biomolecules. These research directions underscore guanine's significance not only as a structural component of nucleic acids but also as an indicator of cellular oxidative stress and genomic integrity in health and disease.
3 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 3 articles above have been cited 12 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Guanine, linking to each citing work.