Enzyme Inhibition and Medicinal Chemistry

Overview

Enzyme inhibition and medicinal chemistry encompass the study of molecules that block or reduce enzyme activity and the design of therapeutic compounds based on these interactions. Research published in New Developments in Chemistry addresses foundational aspects of this field through computational and synthetic approaches to bioactive molecules. One study employed density functional theory to analyze the molecular structure and vibrational properties of a perimidine derivative containing a methoxyphenyl group, providing insights into the electronic characteristics that influence molecular recognition and potential biological activity. Another investigation explored synthetic pathways for producing N-glycosyl amides through both the hydrolysis of protected glycosyl oxazolines and Ritter-like reactions with native carbohydrates, expanding the toolkit for creating glycoconjugate structures relevant to drug development. These contributions matter because understanding molecular structure at the quantum mechanical level and developing efficient synthetic routes to complex scaffolds are essential prerequisites for rational drug design. The ability to predict molecular behavior computationally and to access diverse chemical structures through innovative synthesis enables researchers to explore new candidates for enzyme inhibition, ultimately supporting the discovery of therapeutic agents with improved specificity and efficacy.

Research published in this journal

2 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 2 articles above have been cited 2 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

• Pharmaceutical investigation of 2-Amino-4-(2-fluorophenyl)-5,10-dioxo-5,10-dihydro-4H-benzo[g]chromene-3-carbonitrile via computational studies
  2024 · Inorganic Chemistry Communications
• Pharmaceutical investigation of 2-Amino-4-(2-fluorophenyl)-5,10-dioxo-5,10-dihydro-4H-benzo[g]chromene-3-carbonitrile via computational studies
  2023 · Inorganic Chemistry Communications

A sample of recent works citing this journal's research on Enzyme Inhibition and Medicinal Chemistry, linking to each citing work.

This page summarises published research for orientation; it is not medical or professional advice.

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