Chromatographic techniques are a family of analytical separation methods that resolve the components of a mixture according to their differential partitioning between a stationary phase and a moving mobile phase. Because each analyte interacts with the two phases to a characteristic degree, compounds migrate at diff…
Chromatographic techniques are a family of analytical separation methods that resolve the components of a mixture according to their differential partitioning between a stationary phase and a moving mobile phase. Because each analyte interacts with the two phases to a characteristic degree, compounds migrate at different rates and emerge separately for detection and quantification. The principal modes include gas chromatography, in which volatile analytes are carried by an inert gas, and liquid chromatography, including high-performance liquid chromatography, in which a pressurised solvent elutes analytes through a packed or monolithic column. Coupling chromatography to mass spectrometry, as in LC-MS/MS and GC-MS, adds structural confirmation and high sensitivity, enabling trace determination in complex matrices. These methods are applied across pharmaceutical analysis, for example the quantification of drug substances such as atorvastatin in formulations; biomedical analysis, including measurement of oxidative DNA-damage markers like 8-oxo-2'-deoxyguanosine in urine; food safety and the detection of contaminants of emerging concern; and isotopic abundance studies. Column technology itself is an active area, with hybrid monolithic stationary phases developed to improve the separation of small molecules. Method development addresses resolution, selectivity, detection limits, and the standardisation of test procedures, making chromatography a foundational tool wherever reliable identification and measurement of chemical species are required.
8 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 8 articles above have been cited 47 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Chromatographic Techniques, linking to each citing work.