Basic Helix Loop Helix Domain

Overview

The basic helix-loop-helix domain is a protein structural motif characterized by two alpha helices connected by a loop region, which enables specific DNA binding and protein dimerization in transcription factors. This domain plays a critical role in gene regulation by allowing transcription factors to recognize and bind to specific DNA sequences, thereby controlling the expression of target genes involved in cellular differentiation, development, and immune responses. Research published in New Developments in Chemistry has examined the basic helix-loop helix domain in the context of computational analysis of transcription factor binding sites, particularly investigating how single nucleotide polymorphisms in regulatory regions affect the binding of transcription factors to DNA. This work has explored the relationship between genetic variations and transcription factor binding site recognition, with implications for understanding disease susceptibility and molecular mechanisms underlying immune-related conditions. The topic matters because alterations in transcription factor binding, whether through mutations in the basic helix-loop helix domain itself or in the DNA sequences these domains recognize, can disrupt normal gene regulation and contribute to various pathological states, making this structural motif an important focus for both basic research and translational applications.

Research published in this journal

1 peer-reviewed article, ranked by relevance. Each links to its DOI.

How this research is being cited

The 1 article above has been cited 9 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

• Unraveling Admixture, Inbreeding, and Recent Selection Signatures in West African Indigenous Cattle Populations in Benin
  S. Vanvanhossou et al. · 2021 · Frontiers in Genetics
• Unraveling Admixture, Inbreeding, and Recent Selection Signatures in West African Indigenous Cattle Populations in Benin
  2021 · Frontiers in Genetics
• Identifying Changes in Punitive Transcriptional Factor Binding Sites Created by PPAR α/δ/γ SNPs Associated with Disease
  N. Buroker · 2017 ·
• Identifying Changes in Punitive Transcriptional Factor Binding Sites Created by PPAR<i>α/δ/γ</i> SNPs Associated with Disease
  2017 · Journal of Biosciences and Medicines
• Identifying Alterations in Transcriptional Factor Binding Sites
  2017 · Fetal Neonatal and Developmental Medicine
• SNPs, transcriptional factor binding sites and disease
  2017 · Biomedical Genetics and Genomics
• The 10 bp duplication insertion/deletion in the promoter region within paired box 7 gene is associated with growth traits in cattle
  Yunyun Jin et al. · 2016 ·
• Computational STAT4 rSNP Analysis, Transcriptional Factor Binding Sites And Disease
  2016 · Journal of Bioinformatics and Diabetes

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