Acetonitrile is a colorless, volatile organic solvent widely used in analytical chemistry and organic synthesis due to its miscibility with water and ability to dissolve both polar and nonpolar compounds. Research published in New Developments in Chemistry demonstrates the compound's essential role across multiple a…
Acetonitrile is a colorless, volatile organic solvent widely used in analytical chemistry and organic synthesis due to its miscibility with water and ability to dissolve both polar and nonpolar compounds. Research published in New Developments in Chemistry demonstrates the compound's essential role across multiple analytical and synthetic applications. The journal has documented acetonitrile's use as a mobile phase component in high-performance liquid chromatography methods for pharmaceutical analysis, including the determination of atorvastatin calcium and febuxostat in biological matrices. In synthetic chemistry, articles describe acetonitrile's participation in Ritter-like reactions for preparing N-glycosyl amides from native carbohydrates, as well as its use as a solvent in the synthesis of nucleoside analogues including cladribine and clofarabine. The journal has also featured acetonitrile in chromatographic separation techniques, including its application in hybrid monolithic columns for small molecule separation and in liquid-liquid extraction procedures for quantifying opioids and tramadol from biological samples. Additionally, acetonitrile appears in proteomics workflows involving tandem mass spectrometry and affinity purification methods. These applications underscore acetonitrile's significance as a versatile solvent that enables critical advances in pharmaceutical development, bioanalytical chemistry, and synthetic methodology.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 38 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Acetonitrile, linking to each citing work.