Research Topic · Peer-Reviewed

Creatinine

Creatinine is a waste product of muscle metabolism, formed from the breakdown of creatine and phosphocreatine and excreted by the kidneys, where it is freely filtered at the glomerulus and minimally reabsorbed. For this reason serum and urinary creatinine are foundational biomarkers of renal function, and the estima…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 79× across the literature 🔖 ISSN 2574-4488 🗓 Reviewed June 2026

Overview

Creatinine is a waste product of muscle metabolism, formed from the breakdown of creatine and phosphocreatine and excreted by the kidneys, where it is freely filtered at the glomerulus and minimally reabsorbed. For this reason serum and urinary creatinine are foundational biomarkers of renal function, and the estimated glomerular filtration rate calculated from creatinine underpins the detection and staging of kidney damage. Because creatinine production reflects muscle mass, its interpretation considers body composition alongside other indicators of kidney health, and elevated concentrations may signal reduced filtration from acute or chronic injury, dehydration, obstruction, or nephrotoxic exposure. Research collected here reflects these themes, including reduction in estimated glomerular filtration rate in patients with elevated blood urea nitrogen, the toxicity of iodinated radiographic contrast agents, refractory anaemia with hyperoxaluria, and the evaluation of oxidative and inflammatory markers in maintenance haemodialysis. Further contributions examine polycystic kidney disease, nephrotoxicity models and protective plant compounds, transplant monitoring through Doppler ultrasonography and biopsy, and oxidative DNA-damage markers in urine. Together these peer-reviewed studies span creatinine as a marker of renal function, nephrotoxic and oxidative injury, and the biochemical assessment of kidney health within nephrology.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 12 articles above have been cited 79 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Creatinine, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Nephrology Advances (ISSN 2574-4488).

Journal editorial board
Ying-Yong Zhao · United States Santiago Cuevas · United States Istvan Arany · United States

This page summarises published research for orientation; it is not medical or professional advice.