Santiago Cuevas Ph.D. in Physiology (Universidad de Murcia); (Universidad de Sevilla); B.S. in Biology (Universidad de Murcia)
Children’s National Health System, Washington D.C., District of Columbia · United States
Editorial leadership for Journal of Nephrology Advances ISSN 2574-4488
Research interests
- My Principal Research Interest Is The Physiology Of The Central
- Peripheral Mechanisms Of The Regulation Of Blood Pressure
- Salt Sensitivity
- And The Role Of The Renal Dopaminergic System
- The Oxidative Stress. Essential Hypertension Affects 25% Of The Adult Population. Approximately 14% Of Subjects With Normal Blood Pressure
- About 40% Of Subjects With High Blood Pressure Are Salt-Sensitive. The Genetic
- Molecular
- And Biochemical Mechanisms Of Salt Sensitivity
- Inverse Salt Sensitivity Are Not Well Understood. Dopamine
- Produced By The Kidney
- Independent Of Renal Nerves
- Is Important In The Regulation Of Sodium Balance
- Renal Function
- And Blood Pressure. There Are Two Familes Of Dopamine Receptors: D1-Like (D1R
- D5R)
- D2-Like (D2R
- D3R
- D4R) Receptors
- All Of Which Are Expressed In The Kidney. Impaired Renal Dopamine Production
- Receptor Dysfunction Are Involved In The Pathogenesis Of Human Essential Hypertension
- Rodent Models Of Hypertension. My Research Efforts Have Focused On The Elucidation Of The Roles Of Dj-1
- Pon2 On The D2R Expression
- Function. The Genetic Ablation Of Dj-1
- Pon2
- D2R Results In Hypertension In Mice. My Expertise Is On The Genetics
- Physiology Of Hypertension In Cardiovascular Disorders
Biography
Santiago Cuevas, PhD, is affiliated with Children's National Health System in Washington, D.C., where his research focuses on cardiovascular risk, oxidative stress, and renal pathophysiology. He received his education at Universidad de Murcia and Universidad de Sevilla. His work has examined the role of dopamine receptors, reactive oxygen species, and inflammatory pathways in hypertension and kidney disease, with particular attention to mechanisms involving NADPH oxidase, DJ-1, and paraoxonase 2. His most-cited publication, "NLRP3 Inflammasome and Pyroptosis in Liver Pathophysiology: The Emerging Relevance of Nrf2 Inducers" (2022), has been cited 37 times and reflects his ongoing interest in inflammasome signaling and redox regulation in organ pathophysiology.
Selected publications
- NLRP3 Inflammasome and Pyroptosis in Liver Pathophysiology: The Emerging Relevance of Nrf2 Inducers 2022 cited 37×
- Emerging Role of NLRP3 Inflammasome and Pyroptosis in Liver Transplantation 2022 cited 30×
- Role of Damage-Associated Molecular Patterns (DAMPS) in the Postoperative Period after Colorectal Surgery 2023 cited 23×
- Inflammasomes in Alzheimer’s Progression: Nrf2 as a Preventive Target Recent 2025 cited 6×
- G Protein-Coupled Receptor 37L1 Modulates Epigenetic Changes in Human Renal Proximal Tubule Cells 2022 cited 3×
- SNX19 Interacts with Caveolin-1 and Flotillin-1 to Regulate D1R Endocytosis and Signaling Recent 2025 cited 2×
Ranked by citation impact (Crossref) where available, newest otherwise · verified via ORCID.
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This journal is guided by Santiago Cuevas (Children’s National Health System, Washington D.C., District of Columbia) and a peer-review board of practising researchers. Open access, author-retained copyright (CC BY), and a clear editorial process.