Cancer is a group of diseases characterised by the uncontrolled proliferation of cells that have acquired the capacity to evade normal growth regulation, resist programmed cell death, invade surrounding tissues, and spread to distant sites through metastasis. It arises from the stepwise accumulation of genetic and e…
Cancer is a group of diseases characterised by the uncontrolled proliferation of cells that have acquired the capacity to evade normal growth regulation, resist programmed cell death, invade surrounding tissues, and spread to distant sites through metastasis. It arises from the stepwise accumulation of genetic and epigenetic alterations that activate oncogenes and inactivate tumour-suppressor pathways, conferring the hallmark capabilities of sustained proliferative signalling, replicative immortality, angiogenesis, and immune evasion. Tumours are classified by tissue of origin and behaviour, and clinical management spans prevention, screening, diagnosis, and treatment by surgery, radiotherapy, chemotherapy, targeted agents, and immunotherapy. Major themes include the molecular drivers of metastasis, such as chemokine signalling through receptors like CXCR4 in breast cancer; the contribution of cellular mechanics and therapeutic resistance to relapse; and the epidemiology and organisation of screening programmes for cervical, breast, colorectal, and thyroid cancer across diverse populations. Dietary, lifestyle, and complementary approaches to prevention, as well as the influence of agents such as heparin and statins, are also actively studied. The peer-reviewed research collected under this topic addresses tumour biology and metastatic mechanisms, survival and incidence in cancer cohorts, population-based screening and prevention strategies, and treatment resistance, reflecting the discipline's integration of molecular pathology with clinical and public-health oncology.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 42 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Cancer, linking to each citing work.