Overview
Reciprocal sign epistasis (RSE) is a type of gene interaction where the combined effect of two alleles of a gene is different from the combined effect of their components. It is an important type of gene interaction as it can affect the phenotype of a given organism, with the effect sometimes being more pronounced than that of the individual alleles alone. RSE is used in evolutionary and population genetics as it can help to explain the evolutionary dynamics of a population. Additionally, it is used to uncover genetic constraints that prevent further evolution and thus can be used in the design of genetic modification strategies.
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