Research Topic · Peer-Reviewed

Parkinson's Disease

Parkinson's disease is a chronic, progressive neurodegenerative disorder caused principally by the loss of dopaminergic neurons in the substantia nigra pars compacta and the accumulation of alpha-synuclein aggregates known as Lewy bodies. The resulting dopamine deficiency within the basal ganglia produces the cardin…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 31× across the literature

Overview

Parkinson's disease is a chronic, progressive neurodegenerative disorder caused principally by the loss of dopaminergic neurons in the substantia nigra pars compacta and the accumulation of alpha-synuclein aggregates known as Lewy bodies. The resulting dopamine deficiency within the basal ganglia produces the cardinal motor features of bradykinesia, resting tremor, rigidity, and postural instability, alongside non-motor manifestations including cognitive, autonomic, and neuropsychiatric symptoms such as impulse control disorders. The disease is diagnosed clinically and managed through dopaminergic therapy, with advanced cases addressed by device-aided treatments. Research in this area examines deep brain stimulation of the subthalamic nucleus, including segmented-electrode strategies to reduce side effects, and compares continuous infusion therapies such as apomorphine and levodopa-carbidopa formulations. Further work analyses gait and muscle-activation signals, plasma homocysteine and vascular markers, the prevalence of impulse control disorders, and defective molecular pathways and neurotoxicity models relevant to pathogenesis. Allied strands consider music-based and adjunctive approaches in neurology and the contribution of diet and the microbiota. Symptomatic treatment and quality of life remain central, as no disease-modifying cure exists. The journal publishes peer-reviewed research on Parkinson's disease, including deep brain stimulation, pharmacotherapy, gait analysis, and pathway and neurotoxicity studies.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2015

Epigenetics and Nutrition

Kenneth LundstromCorresponding author
Exact topic International Journal of Nutrition Cited by 2 doi:10.14302/issn.2379-7835.ijn-14-603
2015

Why Music in Neurology?

Alfredo RaglioCorresponding author
Exact topic Journal of Neurological Research and Therapy doi:10.14302/issn.2470-5020.jnrt-14-483

How this research is being cited

The 12 articles above have been cited 31 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Nov 2026.

A sample of recent works citing this journal's research on Parkinson's Disease, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Journal of Memory.

Journal editorial board
Tommaso Piccoli · Italy

This page summarises published research for orientation; it is not medical or professional advice.