Alzheimer's Disease

Overview

Alzheimer's disease is a progressive neurodegenerative disorder and the most common cause of dementia, characterized clinically by insidious decline in memory, language, executive function, and behaviour. Its neuropathological hallmarks are extracellular amyloid-beta plaques and intracellular neurofibrillary tangles of hyperphosphorylated tau, accompanied by synaptic loss, neuroinflammation, and regional atrophy that begins in the medial temporal lobe, including the hippocampus and entorhinal cortex. The disease unfolds across a continuum from a preclinical phase through mild cognitive impairment to overt dementia, and is shaped by genetic risk, vascular factors, and metabolic influences. Research in this area spans early detection and biomarkers, including imaging techniques and serum measures such as cortisol and inflammatory mediators, the molecular biology of the disorder including circular RNAs and other regulatory transcripts, and the distinction between knowledge gaps and misconceptions among caregivers. Further work examines non-pharmacological interventions for disrupted sleep and behavioural symptoms in dementia, the role of nutrition and epigenetics, and emerging therapeutic strategies such as neuromodulation. The condition imposes substantial burden on patients, families, and health systems. The journal publishes peer-reviewed research on Alzheimer's disease, including its molecular pathology, early prediction, caregiver knowledge, and management of associated symptoms.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 12 articles above have been cited 33 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

• Biodynamic lighting versus bright light effects on rest-activity rhythm and night-time sleep in nursing homes residents with dementia
  2026 · BMC Geriatrics
• Peripheral biomarkers of neuroinflammation in Alzheimer’s disease and vascular dementia
  2026 · Biochemical Pharmacology
• Association of peripheral blood NLRP3, sTREM2, and p-tau217 levels with cognitive outcomes in patients with chronic alcohol-related brain damage
  2026 · Alcohol and Alcoholism
• Agitation in dementia and music therapy: A theoretical study of the legitimacy of reductionist music-based interventions
  2026 · Nordic Journal of Music Therapy
• Chronic alcohol consumption induces phenotypic and functional alterations consistent with a hyper-inflammatory state in peripheral blood mononuclear cell-derived microglia in a rhesus macaque model
  Hami Hemati et al. · 2025 · Brain, behavior, and immunity
• Apolipoprotein E (APOE) Isoforms, Neuropsychiatric Symptoms, and Sporadic Alzheimer’s Disease
  2025 ·
• Knowledge and Attitude of Filipino Caregivers of Patients with Dementia Admitted for other Health Issues in a Tertiary Hospital in Metro Manila: A Descriptive Cross-sectional Study
  Raymond U. Tan et al. · 2025 · Acta medica Philippina
• Chronic alcohol consumption induces phenotypic and functional alterations consistent with a hyper-inflammatory state in peripheral blood mononuclear cell-derived microglia in a rhesus macaque model
  2025 · Brain Behavior and Immunity

A sample of recent works citing this journal's research on Alzheimer's Disease, linking to each citing work.

This page summarises published research for orientation; it is not medical or professional advice.

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