Research Topic · Peer-Reviewed

Renin-angiotensin System

The Renin-angiotensin System (RAS) plays a crucial role in regulating the body's blood pressure and fluid balance. It is a hormone system that regulates blood pressure and fluid balance in the body. It involves the interaction of three main components: Renin, Angiotensinogen, and Angiotensin. Renin is an enzyme tha…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 40× across the literature 🔖 ISSN 2578-8590 🗓 Reviewed June 2026

Overview

The Renin-angiotensin System (RAS) plays a crucial role in regulating the body's blood pressure and fluid balance. It is a hormone system that regulates blood pressure and fluid balance in the body. It involves the interaction of three main components: Renin, Angiotensinogen, and Angiotensin. Renin is an enzyme that is produced and secreted by the kidneys when they sense low blood pressure or volume. It acts on a protein in the bloodstream called angiotensinogen, which is produced by the liver, to cleave off a small peptide, forming angiotensin I. Angiotensin I is then converted into Angiotensin II by an enzyme called Angiotensin Converting Enzyme (ACE) which is present in the lungs. Once Angiotensin II is produced, it activates a receptor on the surface of blood vessels causing them to narrow, increasing blood pressure. Angiotensin II also stimulates the secretion of the hormone aldosterone from the adrenal gland, which acts on the kidneys to increase the reabsorption of sodium ions from the urine, leading to an increase in blood volume. Dysregulation of RAS has been implicated in numerous diseases, including hypertension, diabetes, kidney disease, and heart failure. Drugs that target various components of the RAS pathway, such as ACE inhibitors and Angiotensin receptor blockers (ARBs), are widely used to treat hypertension and heart failure. In summary, understanding the Renin-angiotensin system is critical because of its role in maintaining homeostasis and blood pressure regulation. Reviewing this system offers potential pharmaceutical targets to manage cardiovascular and renal conditions.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 12 articles above have been cited 40 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Renin-angiotensin System, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in International Physiology Journal (ISSN 2578-8590).

Journal editorial board
Carola Forster · Germany Ricardo J Fernandes · Portugal Alicja Kuban-Jankowska · Poland

This page summarises published research for orientation; it is not medical or professional advice.