Research Topic · Peer-Reviewed

Systemic Vasculitis

Systemic vasculitis denotes a heterogeneous group of disorders defined by inflammation of blood vessel walls, leading to vessel damage, luminal narrowing or occlusion, aneurysm formation, and ischemic injury to the tissues and organs they supply. Classification is based principally on the caliber of the vessels pred…

Curated from this journal's research 📚 5 peer-reviewed articles cited Cited 5× across the literature 🗓 Reviewed June 2026

Overview

Systemic vasculitis denotes a heterogeneous group of disorders defined by inflammation of blood vessel walls, leading to vessel damage, luminal narrowing or occlusion, aneurysm formation, and ischemic injury to the tissues and organs they supply. Classification is based principally on the caliber of the vessels predominantly affected: large-vessel vasculitis includes giant cell and Takayasu arteritis; medium-vessel disease includes polyarteritis nodosa and Kawasaki disease; and small-vessel vasculitis encompasses the antineutrophil cytoplasmic antibody-associated and immune-complex-mediated forms. Many cases are autoimmune in origin, involving aberrant activation of neutrophils, T cells, and the complement system against vascular endothelium, and vasculitic features can also arise within broader systemic autoimmune conditions and monogenic autoinflammatory syndromes such as deficiency of adenosine deaminase 2. Variable-vessel entities, including Behçet disease, may affect arteries and veins of any size and produce cardiac, neurological, and mucocutaneous manifestations. Common systemic features include fever, weight loss, fatigue, arthralgia, and rash, with organ-specific damage to kidneys, lungs, nerves, skin, and the cardiovascular system. Diagnosis integrates clinical findings, serology, imaging, and histopathology. Treatment is tailored to the subtype and severity and typically combines glucocorticoids with immunosuppressive or biologic agents to induce and maintain remission. Research addresses pathogenesis, classification, and targeted therapy.

Research published in this journal

5 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 5 articles above have been cited 5 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Systemic Vasculitis, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in International Journal of Vasculitis.

Journal editorial board
Bruno Amato · Italy Alessandra Granata · United Kingdom Sophia Lionaki · Greece

This page summarises published research for orientation; it is not medical or professional advice.