Research Topic · Peer-Reviewed

Major Depressive Disorder

Major depressive disorder (MDD) is a common and serious mental-health condition characterized by persistent low mood, loss of interest or pleasure in activities, and a range of cognitive and physical symptoms that impair daily functioning for at least two weeks. Core features include profound sadness, hopelessness, …

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 38× across the literature 🗓 Reviewed July 2026

Overview

Major depressive disorder (MDD) is a common and serious mental-health condition characterized by persistent low mood, loss of interest or pleasure in activities, and a range of cognitive and physical symptoms that impair daily functioning for at least two weeks. Core features include profound sadness, hopelessness, changes in sleep and appetite, fatigue, difficulty concentrating, and feelings of worthlessness, and in severe cases the disorder is associated with suicidal thoughts and behavior. MDD arises from an interplay of biological, psychological, and social factors and frequently co-occurs with chronic physical illnesses such as cancer, dementia, and osteoarthritis, as well as with other mental-health and substance-use disorders. Assessment relies on clinical evaluation, and treatment commonly combines psychotherapy, pharmacotherapy, and psychosocial support. Reflecting the analytical orientation of this neuroinformatics journal, the published research touches on multiple facets of depression, including autobiographical memory and identity development in adolescence in relation to depression, environmental and socioeconomic correlates of depression analyzed at the population level, combined therapy for depressed cancer patients with pain, network-analysis approaches to depressive symptoms among teachers, severity of hopelessness in psychiatric inpatients, the relationship between depression and dementia, and the mental-health status of cancer patients, illustrating clinical, computational, and epidemiological perspectives on the disorder.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2020

Pain between Psyche and Soma in Uro-Andrology

Pruneti CarloCorresponding author
Dept. of Medicine and Surgery, Clinical Psychology, Clinical Psychophysiology and Clinical Neuropsychology Labs., University of Parma, Italy.
Exact topic International Journal of Pain Management Cited by 2 doi:10.14302/issn.2688-5328.ijp-20-3386
2016

Depression and Dementia

Volicer LadislavCorresponding author
School of Aging Studies, University of South Florida, Tampa, FL, USA
Exact topic Depression And Therapy Cited by 2 doi:10.14302/issn.2476-1710.jdt-16-1260

How this research is being cited

The 12 articles above have been cited 38 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Major Depressive Disorder, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in International Journal of Neuroinformatics.

Journal editorial board
Yoshiaki Kikuchi · Japan Dr.Tanzila Saba · Saudi Arabia Haydar Akca · United Arab Emirates

This page summarises published research for orientation; it is not medical or professional advice.