Research Topic · Peer-Reviewed

Atherosclerosis

Atherosclerosis is a chronic, progressive disease of the arterial wall characterized by the accumulation of lipids, inflammatory cells, and fibrous material into plaques that narrow the vessel lumen and stiffen the artery. It begins with endothelial dysfunction and the retention and oxidation of low-density lipoprot…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 55× across the literature 🔖 ISSN 2835-513X 🗓 Reviewed June 2026

Overview

Atherosclerosis is a chronic, progressive disease of the arterial wall characterized by the accumulation of lipids, inflammatory cells, and fibrous material into plaques that narrow the vessel lumen and stiffen the artery. It begins with endothelial dysfunction and the retention and oxidation of low-density lipoprotein in the subintima, prompting monocyte recruitment, foam-cell formation, smooth-muscle proliferation, and the development of a lipid core beneath a fibrous cap. Plaque growth and instability underlie the major cardiovascular events—myocardial infarction, ischemic stroke, and peripheral arterial disease—making atherosclerosis a leading cause of morbidity and mortality. Its risk factors include dyslipidemia, hypertension, diabetes, and smoking, and its assessment uses lipid profiling, carotid intima-media thickness, coronary calcium, and endothelial-function testing. The peer-reviewed research in this area examines atherosclerotic risk, mechanism, and assessment, including comparative analysis of atherosclerosis risk factors in an occupational cohort, the effect of wheat-germ oil on the lipid profile of hypercholesterolemic rats, bioinformatic identification of coronary-disease-associated genes implicated in atherosclerosis pathogenesis, endothelial function across stroke subtypes, microRNAs as therapeutic and diagnostic tools in ischemic heart disease and hypertension, coronary calcification in type 2 diabetes, and carotid intima-media thickness in relation to metabolic factors. Recurring themes include lipid metabolism and dyslipidemia, endothelial and inflammatory mechanisms, the genetic and molecular basis of plaque formation, noninvasive vascular assessment, and dietary and pharmacological strategies for prevention and treatment.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2015

Endothelial Function in Stroke Subtypes Using Endopat Technology

Enrique Jiménez Caballero PedroCorresponding author
Department of Neurology, San Pedro de Alcántara Hospital, Avenida de Pablo Naranjo nº 2, 10003. Cáceres. Spain.
Exact topic Neurological Research and Therapy Cited by 4 doi:10.14302/issn.2470-5020.jnrt-14-558

How this research is being cited

The 12 articles above have been cited 55 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Atherosclerosis, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in International Journal of Lipids (ISSN 2835-513X).

Journal editorial board
Chih-Sheng Chu · Taiwan Anu Puri · United States Hiroshi Yoshida · Japan

This page summarises published research for orientation; it is not medical or professional advice.