Research Topic · Peer-Reviewed

Cox-2 Inhibitors

COX-2 inhibitors are a class of anti-inflammatory drugs that selectively block cyclooxygenase-2, an enzyme induced at sites of inflammation that catalyzes the production of prostaglandins responsible for pain, fever, and inflammation. By targeting COX-2 while largely sparing the constitutively expressed COX-1 enzyme…

Curated from this journal's research 📚 6 peer-reviewed articles cited Cited 14× across the literature 🗓 Reviewed June 2026

Overview

COX-2 inhibitors are a class of anti-inflammatory drugs that selectively block cyclooxygenase-2, an enzyme induced at sites of inflammation that catalyzes the production of prostaglandins responsible for pain, fever, and inflammation. By targeting COX-2 while largely sparing the constitutively expressed COX-1 enzyme that protects the gastric lining, these agents aim to relieve pain and inflammation, as in arthritis, with a lower risk of the gastrointestinal side effects associated with traditional non-selective non-steroidal anti-inflammatory drugs. Their use is balanced against cardiovascular and other safety considerations, and cross-reactivity in patients sensitive to other NSAIDs is an important clinical concern. The International Journal of Inflammation Research is a peer-reviewed, open-access journal covering the biology, pharmacology, and clinical management of inflammation. Its scope is reflected in research directly relevant to these drugs, including a study of cross-reactivity between COX-2 inhibitors in patients with cross-reactive hypersensitivity to NSAIDs, and a randomized placebo-controlled trial showing that etodolac, a preferential COX-2 inhibitor, did not inhibit platelet aggregation, alongside related work on non-steroidal anti-inflammatory drugs in cancer prevention and on novel anti-inflammatory compounds. This page gathers peer-reviewed, open-access research relevant to COX-2 inhibitors and the pharmacology of inflammation.

Research published in this journal

6 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 6 articles above have been cited 14 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Cox-2 Inhibitors, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in International Journal of Inflammation Research.

Journal editorial board
Thomas Boldicke · Germany Graziella Curtale · Italy Frederic Velard · France

This page summarises published research for orientation; it is not medical or professional advice.