Research Topic · Peer-Reviewed

Major Depression

Major depression, also known as major depressive disorder, is a serious and often debilitating mood disorder defined by persistent low mood and loss of interest or pleasure, together with disturbances of sleep, appetite, energy, concentration, and self-worth, and at times thoughts of death or suicide, sustained over…

Curated from this journal's research 📚 11 peer-reviewed articles cited Cited 23× across the literature 🔖 ISSN 2997-1969 🗓 Reviewed June 2026

Overview

Major depression, also known as major depressive disorder, is a serious and often debilitating mood disorder defined by persistent low mood and loss of interest or pleasure, together with disturbances of sleep, appetite, energy, concentration, and self-worth, and at times thoughts of death or suicide, sustained over time and impairing daily life. It is highly prevalent and a leading contributor to disability worldwide, arising from the interplay of genetic, neurobiological, psychological, and social factors. Viewed through the lens of health statistics, major depression is studied by its frequency, severity, determinants, and outcomes across populations, with attention to how risk varies by gender, occupation, life stage, and environmental and socioeconomic exposures. Statistical and network analytic methods characterise the structure of depressive symptoms, identify core and activating features, and clarify associations with comorbid conditions and contextual factors such as environmental noise. Major depression frequently coexists with cognitive impairment and dementia, with chronic illness, pain, and cancer, and with related states such as apathy from which it must be distinguished; neurobiological correlates including cortisol dysregulation and medial temporal lobe atrophy have been described. Measurement of severity, including hopelessness and suicide risk, relies on validated instruments. By applying statistical approaches to the patterns, determinants, and burden of major depression, this field informs prevention and the evidence base for care.

Research published in this journal

11 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2016

Depression and Dementia

Volicer LadislavCorresponding author
School of Aging Studies, University of South Florida, Tampa, FL, USA
Exact topic Depression And Therapy Cited by 2 doi:10.14302/issn.2476-1710.jdt-16-1260
2020

Pain between Psyche and Soma in Uro-Andrology

Pruneti CarloCorresponding author
Dept. of Medicine and Surgery, Clinical Psychology, Clinical Psychophysiology and Clinical Neuropsychology Labs., University of Parma, Italy.
Exact topic International Journal of Pain Management Cited by 2 doi:10.14302/issn.2688-5328.ijp-20-3386

How this research is being cited

The 11 articles above have been cited 23 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Major Depression, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in International Journal of Health Statistics (ISSN 2997-1969).

Journal editorial board
Mairead Bermingham · United Kingdom Naghmeh Mirhosseini · Canada Nunzia Nappo · Italy

This page summarises published research for orientation; it is not medical or professional advice.