Cytoplasmic staining refers to the visualization of proteins, molecules, or cellular components within the cytoplasm of cells using histochemical or immunohistochemical techniques, enabling researchers to determine the localization and expression patterns of specific biomarkers. Research published in this journal ad…
Cytoplasmic staining refers to the visualization of proteins, molecules, or cellular components within the cytoplasm of cells using histochemical or immunohistochemical techniques, enabling researchers to determine the localization and expression patterns of specific biomarkers. Research published in this journal addresses cytoplasmic staining in diverse contexts, including the detection of aberrant protein localization with functional consequences, such as cytoplasmic retention of cell cycle regulators that can trigger premature senescence and affect tumor suppression. Studies have employed cytoplasmic staining to evaluate insulin receptor substrate protein expression in breast cancer tissue as part of prognostic scoring systems, and to assess the distribution of RNA-binding proteins across cellular compartments in evolutionary and disease contexts. The journal has also published work using cytoplasmic markers like p16/INK4a and Ki-67 to distinguish between benign and intraepithelial cervical lesions through immunohistochemical analysis, as well as investigations of cytoplasmic characteristics in soft tissue tumors such as perineuriomas. These applications demonstrate that cytoplasmic staining serves as a critical tool for understanding protein mislocalization, cellular dysfunction, and diagnostic pathology across cancer biology and related fields.
5 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 5 articles above have been cited 7 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Cytoplasmic Staining, linking to each citing work.