Research Topic · Peer-Reviewed

Antiviral Therapies for Coronaviruses

Antiviral therapies for coronaviruses are treatments designed to inhibit infection by coronaviruses, RNA viruses that include the agent of COVID-19, SARS-CoV-2. They aim to interrupt stages of the viral life cycle such as entry, replication, and protein processing, or to modulate the host response that drives diseas…

Curated from this journal's research 📚 9 peer-reviewed articles cited Cited 21× across the literature 🔖 ISSN 2692-1537 🗓 Reviewed June 2026

Overview

Antiviral therapies for coronaviruses are treatments designed to inhibit infection by coronaviruses, RNA viruses that include the agent of COVID-19, SARS-CoV-2. They aim to interrupt stages of the viral life cycle such as entry, replication, and protein processing, or to modulate the host response that drives disease severity. Because no single agent reliably controls severe coronavirus infection, research spans direct-acting antivirals and immunomodulatory strategies. Host-directed approaches feature prominently, including the use of immune modulators such as interferon-gamma to support antiviral defense and examination of how the viral spike protein influences interferon signaling and cytokine gene expression. Repurposed agents have also been evaluated, exemplified by studies of hydroxychloroquine and its effect on clinical improvement and mortality, reflecting efforts to identify existing drugs with activity against the virus. Therapeutic development is informed by molecular characterization of SARS-CoV-2, including evolutionary analysis of spike glycoprotein sequences that identifies conserved targets and tracks variation relevant to drug efficacy. Mechanistic understanding of how the virus enters and reprograms cells guides the selection of intervention points. Antiviral therapy for coronaviruses thus combines virology, pharmacology, and immunology to design and assess treatments that reduce viral burden, limit harmful inflammation, and improve outcomes across the spectrum of coronavirus disease.

Research published in this journal

9 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 9 articles above have been cited 21 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Antiviral Therapies for Coronaviruses, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in International Journal of Coronaviruses (ISSN 2692-1537).

Journal editorial board
Dr. Omeed Memar · USA Dr. SUDIPTI GUPTA · United States Dr. Jose Luis Turabian · Spain

This page summarises published research for orientation; it is not medical or professional advice.